Hannedouche T, Choukroun G, Delgado A, Boitard C, Lacour B, Grünfeld J P
Département de Néphrologie, Hôpital Necker, Paris, France.
Miner Electrolyte Metab. 1990;16(1):12-5.
The determinants of ciclosporin A-induced blood pressure changes were analyzed initially and after 3 months in 30 recent type I diabetics submitted to chronic treatment with ciclosporin as single immunosuppressive drug. Prevalence of hypertension was 17% and relatively low as compared to those reported in organ transplantation. Ciclosporin induced a slight decrease in glomerular filtration rate and renal plasma flow, with unchanged filtration fraction, a mild average increase in blood pressure and a more pronounced increase in renal vascular resistance. There was a trend toward decrease in absolute urinary sodium excretion whereas fractional excretion of sodium was unchanged. Presence of familial history of essential hypertension was characterized by a slightly insignificantly lower renal plasma flow and did not affect the renal effect of ciclosporin except that the renal plasma flow was significantly lower in the groups of patients genetically predisposed.
对30例近期诊断为I型糖尿病且正在接受环孢素单一免疫抑制药物长期治疗的患者，在治疗初期及3个月后分析了环孢素A诱导血压变化的决定因素。高血压患病率为17%，与器官移植中报道的患病率相比相对较低。环孢素使肾小球滤过率和肾血浆流量略有下降，滤过分数不变，平均血压轻度升高，肾血管阻力升高更为明显。尿钠排泄绝对值有下降趋势，而钠分数排泄不变。原发性高血压家族史的特点是肾血浆流量略低但无显著差异，除了在有遗传易感性的患者组中肾血浆流量显著较低外，不影响环孢素的肾脏效应。
