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Geropotency: increased malignant potential of aging neural progenitors.

作者信息

Mikheev Andrei M, Stoll Elizabeth A, Ramakrishna Rohan, Mikheeva Svetlana A, Horner Philip J, Rostomily Robert C

出版信息

Aging (Albany NY). 2012 Dec;4(12):854-5. doi: 10.18632/aging.100514.

DOI:10.18632/aging.100514
PMID:23257545
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3615151/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b78/3615151/93ac06593b56/aging-04-854-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b78/3615151/93ac06593b56/aging-04-854-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b78/3615151/93ac06593b56/aging-04-854-g001.jpg

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4
CDK4/6-inhibiting drug substitutes for p21 and p16 in senescence: duration of cell cycle arrest and MTOR activity determine geroconversion.CDK4/6 抑制剂在衰老中替代 p21 和 p16：细胞周期阻滞的持续时间和 MTOR 活性决定了衰老的转化。
Cell Cycle. 2013 Sep 15;12(18):3063-9. doi: 10.4161/cc.26130. Epub 2013 Aug 22.
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Increased re-entry into cell cycle mitigates age-related neurogenic decline in the murine subventricular zone.细胞周期再进入可减轻小鼠侧脑室下区与年龄相关的神经发生衰退。
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