肉碱乙酰转移酶活性在大鼠脑和人血小板中不会随年龄变化。
Carnitine acetyltransferase activity is not changed with age in rat brain and human platelets.
作者信息
Moret C, Pastrie I, Briley M
机构信息
Centre de Recherche Pierre Fabre, Castres, France.
出版信息
Neurobiol Aging. 1990 Jan-Feb;11(1):57-9. doi: 10.1016/0197-4580(90)90063-6.
Carnitine acetyltransferase activity was studied in different brain regions of the rat and in human platelets. The values of Km for carnitine and for acetyl-CoenzymeA (acetyl-CoA) were similar in cortex, hippocampus and striatum of the rat and in human platelets, suggesting that carnitine acetyltransferase might be a useful peripheral marker of its central activity. The activity of this enzyme was similar in the cortex and hippocampus of young and old rats. Furthermore, the determination of carnitine acetyltransferase activity in platelets from healthy volunteers showed no significant difference with age.
在大鼠的不同脑区以及人类血小板中研究了肉碱乙酰转移酶活性。大鼠的皮质、海马体和纹状体以及人类血小板中肉碱和乙酰辅酶A（acetyl-CoA）的Km值相似，这表明肉碱乙酰转移酶可能是其中枢活性的一种有用的外周标志物。该酶在年轻和老年大鼠的皮质和海马体中的活性相似。此外，对健康志愿者血小板中肉碱乙酰转移酶活性的测定显示，其活性随年龄无显著差异。
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