Moriwaki A, Hattori Y, Nishida N, Hori Y
Department of Physiology, Okayama University Medical School, Japan.
Neurosci Lett. 1990 Mar 2;110(1-2):72-6. doi: 10.1016/0304-3940(90)90789-c.
Electrocorticograms were recorded from rats which were unilaterally injected with ferrous chloride solution into the sensorimotor cortex to induce chronic epileptic activity. All of the iron-injected rats showed isolated spikes near the injection site and in the contralateral cortex immediately after the injection. The injection produced 3 kinds of responses in the rats according to the frequency of the isolated spikes. Spike and wave complexes appeared bilaterally approximately 30 days or more after the injection in the rats in which the frequency of the isolated spikes was dominant on the side ipsilateral to the injection site or nearly equal on the two sides. These results suggest that there are at least 2 stages in the development of chronic iron-induced epilepsy.
对大鼠进行皮质电图记录，这些大鼠被单侧注射氯化亚铁溶液到感觉运动皮层以诱导慢性癫痫活动。所有注射铁剂的大鼠在注射后立即在注射部位附近和对侧皮层出现孤立的棘波。根据孤立棘波的频率，注射在大鼠中产生了3种反应。在注射部位同侧孤立棘波频率占优势或两侧频率几乎相等的大鼠中，注射后约30天或更长时间双侧出现棘波和慢波综合波。这些结果表明，慢性铁诱导癫痫的发展至少有2个阶段。
