• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Melphalan Culprit or Confounder in Acute Encephalopathy during Autologous Hematopoietic Stem Cell Transplantation?美法仑是自体造血干细胞移植期间急性脑病的罪魁祸首还是混淆因素？
Case Rep Transplant. 2012;2012:942795. doi: 10.1155/2012/942795. Epub 2012 May 7.
2
Autologous haematopoietic stem-cell transplantation versus bortezomib-melphalan-prednisone, with or without bortezomib-lenalidomide-dexamethasone consolidation therapy, and lenalidomide maintenance for newly diagnosed multiple myeloma (EMN02/HO95): a multicentre, randomised, open-label, phase 3 study.自体造血干细胞移植对比硼替佐米-美法仑-泼尼松（联合或不联合硼替佐米-来那度胺-地塞米松巩固治疗）以及来那度胺维持治疗用于新诊断的多发性骨髓瘤（EMN02/HO95）：一项多中心、随机、开放标签的3期研究
Lancet Haematol. 2020 Jun;7(6):e456-e468. doi: 10.1016/S2352-3026(20)30099-5. Epub 2020 Apr 30.
3
Hypercytokinemia-induced metabolic encephalopathy in a multiple myeloma patient on hemodialysis undergoing autologous stem cell transplantation: clinical response after plasma exchange.血液透析多发性骨髓瘤自体干细胞移植患者细胞因子血症相关代谢性脑病：血浆置换后的临床疗效
Transpl Immunol. 2009 Sep;21(4):240-3. doi: 10.1016/j.trim.2009.06.002. Epub 2009 Jun 16.
4
Feasibility of second hematopoietic stem cell transplantation using reduced-intensity conditioning with fludarabine and melphalan after a failed autologous hematopoietic stem cell transplantation.在自体造血干细胞移植失败后，使用氟达拉滨和马法兰进行减低剂量预处理进行第二次造血干细胞移植的可行性。
Transplant Proc. 2010 Nov;42(9):3723-8. doi: 10.1016/j.transproceed.2010.09.005.
5
Oral mucositis and outcomes of autologous hematopoietic stem-cell transplantation following high-dose melphalan conditioning for multiple myeloma.多发性骨髓瘤大剂量美法仑预处理后自体造血干细胞移植的口腔黏膜炎及预后
J Support Oncol. 2007 May;5(5):231-5.
6
[Autologous haematopoietic stem cell transplantation in patients with multiple myeloma complicated by dialysis-dependent renal failure].[自体造血干细胞移植治疗合并依赖透析的肾衰竭的多发性骨髓瘤患者]
Ter Arkh. 2020 Sep 1;92(7):70-76. doi: 10.26442/00403660.2020.07.000777.
7
Autologous stem cell transplantation for multiple myeloma: Long-term results.多发性骨髓瘤的自体干细胞移植：长期结果
Natl Med J India. 2016 Jul-Aug;29(4):192-199.
8
[Complete remission of nephrotic syndrome and improvement of renal function in a patient with light chain deposition disease following high dose chemotherapy with transplantation of autologous haematopoietic stem cells. A case study and review of literature].[一名轻链沉积病患者在接受高剂量化疗并自体造血干细胞移植后肾病综合征完全缓解且肾功能改善。一项病例研究及文献综述]
Vnitr Lek. 2009 Nov;55(11):1089-96.
9
Busulfan, Melphalan, and Bortezomib versus High-Dose Melphalan as a Conditioning Regimen for Autologous Hematopoietic Stem Cell Transplantation in Multiple Myeloma.白消安、美法仑和硼替佐米与大剂量美法仑作为多发性骨髓瘤自体造血干细胞移植预处理方案的比较
Biol Blood Marrow Transplant. 2016 Aug;22(8):1391-1396. doi: 10.1016/j.bbmt.2016.03.021. Epub 2016 May 7.
10
A Phase I/II Study of Escalating Doses of Bortezomib in Conjunction with High-Dose Melphalan as a Conditioning Regimen for Salvage Autologous Peripheral Blood Stem Cell Transplantation in Patients with Multiple Myeloma.一项关于递增剂量硼替佐米联合大剂量美法仑作为多发性骨髓瘤患者挽救性自体外周血干细胞移植预处理方案的I/II期研究。
Biol Blood Marrow Transplant. 2016 Dec;22(12):2165-2171. doi: 10.1016/j.bbmt.2016.08.017. Epub 2016 Aug 31.

引用本文的文献

1
Melphalan-associated encephalopathy following autologous stem cell transplant: a transplanter's nightmare!自体干细胞移植后美法仑相关脑病：移植医生的噩梦！
Blood Cell Ther. 2024 Mar 15;7(2):33-36. doi: 10.31547/bct-2023-025. eCollection 2024 May 25.
2
How we manage autologous stem cell transplantation for patients with multiple myeloma.我们如何为多发性骨髓瘤患者管理自体干细胞移植。
Blood. 2014 Aug 7;124(6):882-90. doi: 10.1182/blood-2014-03-544759. Epub 2014 Jun 27.

本文引用的文献

1
Pre- and post-transplantation risk factors for delirium onset and severity in patients undergoing hematopoietic stem-cell transplantation.造血干细胞移植患者发生谵妄及严重程度的移植前后危险因素。
J Clin Oncol. 2011 Mar 1;29(7):895-901. doi: 10.1200/JCO.2010.28.4521. Epub 2011 Jan 24.
2
Wernicke's encephalopathy following allogeneic hematopoietic stem cell transplantation.异基因造血干细胞移植后韦尼克脑病
Korean J Hematol. 2010 Dec;45(4):279-81. doi: 10.5045/kjh.2010.45.4.279. Epub 2010 Dec 31.
3
Treatment of severe sepsis and septic shock by CHDF using a PMMA membrane hemofilter as a cytokine modulator.使用聚甲基丙烯酸甲酯（PMMA）膜血液滤过器作为细胞因子调节剂，通过连续性血液透析滤过（CHDF）治疗严重脓毒症和脓毒性休克。
Contrib Nephrol. 2010;166:73-82. doi: 10.1159/000314855. Epub 2010 May 7.
4
Posterior reversible encephalopathy syndrome: associated clinical and radiologic findings.后部可逆性脑病综合征：相关临床和影像学表现。
Mayo Clin Proc. 2010 May;85(5):427-32. doi: 10.4065/mcp.2009.0590.
5
Hypercytokinemia-induced metabolic encephalopathy in a multiple myeloma patient on hemodialysis undergoing autologous stem cell transplantation: clinical response after plasma exchange.血液透析多发性骨髓瘤自体干细胞移植患者细胞因子血症相关代谢性脑病：血浆置换后的临床疗效
Transpl Immunol. 2009 Sep;21(4):240-3. doi: 10.1016/j.trim.2009.06.002. Epub 2009 Jun 16.
6
Neurological complications of hematopoietic stem cell transplantation (HSCT): a retrospective study in a HSCT center in Brazil.造血干细胞移植（HSCT）的神经并发症：巴西一家HSCT中心的回顾性研究。
Arq Neuropsiquiatr. 2008 Sep;66(3B):685-90. doi: 10.1590/s0004-282x2008000500014.
7
Central nervous system complications after allogeneic hematopoietic stem cell transplantation: incidence, manifestations, and clinical significance.异基因造血干细胞移植后的中枢神经系统并发症：发生率、表现及临床意义。
Biol Blood Marrow Transplant. 2007 Nov;13(11):1369-79. doi: 10.1016/j.bbmt.2007.07.013. Epub 2007 Sep 21.
8
TNF is a key mediator of septic encephalopathy acting through its receptor, TNF receptor-1.肿瘤坏死因子（TNF）是脓毒症脑病的关键介质，通过其受体肿瘤坏死因子受体-1发挥作用。
Neurochem Int. 2008 Feb;52(3):447-56. doi: 10.1016/j.neuint.2007.08.006. Epub 2007 Aug 17.
9
Continuous hemodiafiltration with cytokine-adsorbing hemofilter in the treatment of severe sepsis and septic shock.采用细胞因子吸附血液滤过器进行连续性血液透析滤过治疗严重脓毒症和脓毒性休克。
Contrib Nephrol. 2007;156:365-70. doi: 10.1159/000102127.
10
Spectrum and prognosis of neurologic complications after hematopoietic transplantation.造血移植后神经系统并发症的谱系和预后
Neurology. 2006 Dec 12;67(11):1990-7. doi: 10.1212/01.wnl.0000247038.43228.17.

美法仑是自体造血干细胞移植期间急性脑病的罪魁祸首还是混淆因素？

Melphalan Culprit or Confounder in Acute Encephalopathy during Autologous Hematopoietic Stem Cell Transplantation?

作者信息

Alayón-Laguer Diógenes, Alsina Melissa, Ochoa-Bayona Jose L, Ayala Ernesto

机构信息

Hematology-Oncology Program San Juan City Hospital and VA Caribbean Healthcare System, 10 Calle Casia, San Juan, PR 00921, USA.

出版信息

Case Rep Transplant. 2012;2012:942795. doi: 10.1155/2012/942795. Epub 2012 May 7.

DOI:10.1155/2012/942795
PMID:23259145
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3505956/
Abstract

We report a case of a female patient with Durie-Salmon stage 3A/ISS stage I IgG kappa multiple myeloma (MM) who developed encephalopathy after high-dose melphalan and hematopoietic stem cell transplant (HSCT). The most common etiologies for encephalopathy such as infection, narcotic medications, metabolic-electrolyte disturbance, stroke, and central nervous system (CNS) hemorrhages were ruled out. The patient recovered from the altered mental status spontaneously. The possibilities of melphalan-induced encephalopathy versus critical-state delirium versus hypercytokinemia induce encephalopathy were contemplated.

摘要

我们报告了一例Durie-Salmon 3A期/国际分期系统（ISS）I期IgG κ型多发性骨髓瘤（MM）女性患者，其在接受大剂量美法仑和造血干细胞移植（HSCT）后发生了脑病。脑病最常见的病因，如感染、麻醉药物、代谢电解质紊乱、中风和中枢神经系统（CNS）出血，均被排除。患者的精神状态改变自行恢复。我们考虑了美法仑诱发的脑病、危重症谵妄与高细胞因子血症诱发脑病的可能性。