Teive Hélio A G, Funke Vaneuza, Bitencourt Marco A, de Oliveira Michel Michels, Bonfim Carmen, Zanis-Neto José, Medeiros Carlos R de, Zétola Viviane F, Werneck Lineu César, Pasquini Ricardo
Neurology Service, Internal Medicine Department, Hospital de Clínicas, Federal University of Paraná, Curitiba, PR, Brazil.
Arq Neuropsiquiatr. 2008 Sep;66(3B):685-90. doi: 10.1590/s0004-282x2008000500014.
We present the neurological complications evaluated in a series of 1000 patients who underwent hematopoietic stem cell transplantation (HSCT). Central nervous system (CNS) neurological complications, particularly brain hemorrhages, were the most common, followed by seizures and CNS infections. An unusual neurological complication was Wernicke's encephalopathy. Less frequent neurological complications were metabolic encephalopathy, neuroleptic malignant syndrome, reversible posterior leukoencephalopathy syndrome, brain infarct and movement disorders. The most common neurological complication of the peripheral nervous system was herpes zoster radiculopathy, while peripheral neuropathies, inflammatory myopathy and myotonia were very rarely found.
我们展示了对1000例接受造血干细胞移植（HSCT）患者所评估的神经并发症情况。中枢神经系统（CNS）神经并发症，尤其是脑出血，最为常见，其次是癫痫发作和CNS感染。一种不寻常的神经并发症是韦尼克脑病。不太常见的神经并发症有代谢性脑病、抗精神病药恶性综合征、可逆性后部白质脑病综合征、脑梗死和运动障碍。外周神经系统最常见的神经并发症是带状疱疹性神经根病，而外周神经病变、炎性肌病和肌强直则非常罕见。
