Sugiyama Haruo
Department of Functional Diagnostic Science, Osaka University Graduate School of Medicine.
Nihon Rinsho. 2012 Dec;70(12):2105-13.
Wilms' tumor gene WT1 encodes a transcription factor and functions as an oncogene. WT1 gene product WT1 protein is a promising par-tumor-associated antigen. WT1 peptide-based immunotherapy has been performing for more than six hundred patients with leukemias and various types of solid tumors. This immunotherapy is safe and has clinical benefit especially for leukemia, glioblastoma multiforme, advanced pancreatic cancer, and ovarian cancer. As a new strategy for cancer treatment, it should be recommended to initiate immunotherapy that had a potential of eradication of cancer stem cells before surgery, chemo- and radio-therapy.
肾母细胞瘤基因WT1编码一种转录因子，起癌基因的作用。WT1基因产物WT1蛋白是一种很有前景的肿瘤相关抗原。基于WT1肽的免疫疗法已应用于600多名白血病和各类实体瘤患者。这种免疫疗法是安全的，尤其对白血病、多形性胶质母细胞瘤、晚期胰腺癌和卵巢癌具有临床益处。作为一种癌症治疗的新策略，在手术、化疗和放疗之前，应推荐启动具有根除癌症干细胞潜力的免疫疗法。
