Kakimi Kazuhiro, Kondo Atsushi, Matsushita Hirokazu
Department of Immunotherapeutics, The University of Tokyo Hospital.
Nihon Rinsho. 2012 Dec;70(12):2130-5.
Dendritic cells (DC) are the antigen presenting cells that initiate and regulate immunity. There are distinct DC subsets with specialized functions spread throughout the body. The type of immune response is determined by the DC subsets involved. Therefore, it is important to understand distinct phenotype and functions of these DC subsets in terms of antigen uptake and processing for MHC class I- and II-restricted presentation and receptors for foreign and endogenous signals. These insights facilitate the direct targeting of antigens to DC surface receptors in vivo rather than ex vivo culturing DC and antigen loading. In addition, novel DC immunotherapies will be in combination with drugs targeting immunological check points.
树突状细胞（DC）是启动和调节免疫的抗原呈递细胞。在全身分布着具有特殊功能的不同DC亚群。免疫反应的类型由所涉及的DC亚群决定。因此，了解这些DC亚群在MHC I类和II类限制性呈递的抗原摄取和加工以及外来和内源性信号受体方面的不同表型和功能非常重要。这些见解有助于在体内将抗原直接靶向DC表面受体，而不是在体外培养DC并加载抗原。此外，新型DC免疫疗法将与靶向免疫检查点的药物联合使用。
