Department of Obstetrics and Gynaecology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany.
Arch Gynecol Obstet. 2013 Jun;287(6):1205-9. doi: 10.1007/s00404-012-2682-y. Epub 2012 Dec 20.
We sought to evaluate clinical and oncologic outcomes of selected patients with locally advanced breast cancer undergoing full thickness chest wall resection (FTCWR) and reconstruction in a multidisciplinary setting.
Between 2008 and 2010, five women underwent FTCWR followed by chest wall repair for locally advanced primary breast cancer. In all cases, chest wall repair was performed with a Peri-Guard Repair Patch (Synovis, St. Paul, MN, USA). At follow-up (7-12 months) quality of life, respiratory function and oncologic status were assessed.
Successful chest wall resection and repair were achieved in all patients. Plastic reconstruction of post-mastectomy tissue defects was necessary in one case. One patient was treated by breast conserving therapy. Chest ultrasound imaging confirmed absence of adhesions, haematoma or seroma and normal expansion and respiratory movement of the underlying lung in all patients. On follow-up all patients reported good quality of life.
Multidisciplinary surgical approaches to chest wall resection and reconstruction in selected patients with locally advanced primary breast cancer are feasible, safe, associated with short operation time and hospital stay and negligible morbidity.
我们旨在评估在多学科环境下接受全层胸壁切除术（FTCWR）和重建的局部晚期乳腺癌患者的临床和肿瘤学结果。
2008 年至 2010 年间，5 名女性因局部晚期原发性乳腺癌接受了 FTCWR 及胸壁修复。在所有情况下，均使用 Peri-Guard 修复补片（Synovis，St. Paul，MN，USA）进行胸壁修复。在随访（7-12 个月）时，评估生活质量、呼吸功能和肿瘤状况。
所有患者均成功完成了胸壁切除和修复。1 例患者需要进行乳房切除术后组织缺损的整形重建。1 例患者接受了保乳治疗。胸部超声成像证实所有患者均无粘连、血肿或血清肿，且底层肺的扩张和呼吸运动正常。在随访时，所有患者均报告生活质量良好。
对于局部晚期原发性乳腺癌患者，采用多学科方法进行胸壁切除术和重建是可行的、安全的，手术时间和住院时间短，发病率低。
