Young V L, Talley A R, Pin P, Trick G L, Becker W, Logan S E, Kraemer B A
Department of Ophthalmology, Washington University School of Medicine, St. Louis, Mo.
Plast Reconstr Surg. 1990 May;85(5):698-703; discussion 704-5.
An experimental model has been developed to measure the effect of retrobulbar hematomas on functional vision in cynomolgus monkeys. In this model, functional vision was quantitated using flashed evoked visual potentials in five monkeys following creation of retrobulbar hematomas. In one monkey used as a control, functional vision remained impaired for 180 minutes following induction of retinal ischemia by increased intraorbital pressure. In two monkeys in which increased intraorbital pressure was relieved by anterior chamber paracentesis following 15 minutes of retinal ischemia, flashed evoked visual potential promptly returned to baseline level. In two additional monkeys in which increased intraorbital pressure was relieved following 30 minutes of retinal ischemia, flashed evoked visual potentials improved but never returned to baseline levels. This study demonstrates the usefulness of flashed evoked visual potentials in measuring functional vision in cynomolgus monkeys. This experimental model should prove useful in evaluating the effects of increased intraorbital pressure on functional vision and the effect of intervention on impaired vision due to retrobulbar hematomas. Further studies with larger numbers of animals are needed to clarify these preliminary studies and document longer-term effects of retinal ischemia secondary to retrobulbar hematomas.
已建立一种实验模型来测量球后血肿对食蟹猴功能性视力的影响。在该模型中，通过在五只食蟹猴形成球后血肿后使用闪光视觉诱发电位来定量功能性视力。在一只用作对照的猴子中，通过增加眶内压诱导视网膜缺血后，功能性视力在180分钟内仍受损。在两只猴子中，在视网膜缺血15分钟后通过前房穿刺术缓解眶内压升高，闪光视觉诱发电位迅速恢复到基线水平。在另外两只猴子中，在视网膜缺血30分钟后缓解眶内压升高，闪光视觉诱发电位有所改善但从未恢复到基线水平。本研究证明了闪光视觉诱发电位在测量食蟹猴功能性视力方面的有用性。该实验模型在评估眶内压升高对功能性视力的影响以及干预对球后血肿所致视力受损的影响方面应被证明是有用的。需要用更多数量的动物进行进一步研究，以阐明这些初步研究并记录球后血肿继发视网膜缺血的长期影响。
