Okubo Keita, Hama Naoki, Kobayashi Shogo, Eguchi Hidetoshi, Akita Hirofumi, Wada Hiroshi, Kawamoto Koichi, Marubashi Shigeru, Tanemura Masahiro, Umeshita Koji, Mori Masaki, Doki Yuichiro, Nagano Hiroaki
Dept. of Surgery, Osaka University Graduate School of Medicine, Japan.
Gan To Kagaku Ryoho. 2012 Nov;39(12):2140-2.
Recently, the number of case reports detailing cancer recurrence in the pancreatic remnants, following surgical resection of intraductal papillary-mucinous carcinoma (IPMC) of the pancreas has increased. We report the case of a 74-year-old woman who underwent pancreatic resection twice in a 3-year period for primary IPMC and remnant pancreatic ductal carcinoma. We first performed distal pancreatectomy for branched IPMC in the pancreatic tail. Histopathological examination revealed invasive IPMC and the negative margin of the pancreatic duct. The expression of tumor markers gradually increased in the 2 years and 4 months after the initial surgery, and a tumor was detected in the remnant pancreas. We performed total remnant pancreatectomy. The recurrent tumor consisted of moderately differentiated adenocarcinoma. Currently, the patient is alive without recurrence for a year since the second resection. This experience suggests that careful surveillance is necessary for IPMC.
最近,详细描述胰腺导管内乳头状黏液性癌(IPMC)手术切除后胰腺残端癌症复发的病例报告数量有所增加。我们报告了一例74岁女性患者,在3年期间因原发性IPMC和残留胰腺导管癌接受了两次胰腺切除术。我们首先对胰腺尾部的分支型IPMC进行了远端胰腺切除术。组织病理学检查显示为浸润性IPMC,胰腺导管切缘阴性。在初次手术后的2年4个月里,肿瘤标志物的表达逐渐升高,并且在残留胰腺中检测到一个肿瘤。我们进行了全残留胰腺切除术。复发性肿瘤为中分化腺癌。目前,自第二次切除术后,患者已存活一年且无复发。这一经验表明,对IPMC进行仔细监测是必要的。