Yamamoto Seiichi
Department of Radiological and Medical Laboratory Sciences, Nagoya University, Graduate School of Medicine, 1-1-20 Daiko-Minami, Higashi-ku, Nagoya 461-8673, Japan.
Radiol Phys Technol. 2013 Jul;6(2):281-6. doi: 10.1007/s12194-012-0195-9. Epub 2012 Dec 28.
The silicon photomultiplier (Si-PM) is a promising photodetector for PET. However, it remains unclear whether Si-PM can be used for a depth-of-interaction (DOI) detector based on the decay time differences of the scintillator where pulse shape analysis is used. For clarification, we tested the Hamamatsu 4 × 4 Si-PM array (S11065-025P) combined with scintillators that used different decay times to develop DOI block detectors using the pulse shape analysis. First, Ce-doped Gd(2)SiO(5) (GSO) scintillators of 0.5 mol% Ce were arranged in a 4 × 4 matrix and were optically coupled to the center of each pixel of the Si-PM array for measurement of the energy resolution as well as its gain variations according to the temperature. Then two types of Ce-doped Lu(1.9)Gd(0.1)Si0(5) (LGSO) scintillators, 0.025 mol% Ce (decay time: ~31 ns) and 0.75 mol% Ce (decay time: ~46 ns), were optically coupled in the DOI direction, arranged in a 11 × 7 matrix, and optically coupled to a Si-PM array for testing of the possibility of a high-resolution DOI detector. The energy resolution of the Si-PM array-based GSO block detector was 18 ± 4.4 % FWHM for a Cs-137 gamma source (662 keV). Less than 1 mm crystals were clearly resolved in the position map of the LGSO DOI block detector. The peak-to-valley ratio (P/V) derived from the pulse shape spectra of the LGSO DOI block detector was 2.2. These results confirmed that Si-PM array-based DOI block detectors are promising for high-resolution small animal PET systems.
硅光电倍增管(Si-PM)是一种很有前景的正电子发射断层扫描(PET)光电探测器。然而,基于脉冲形状分析利用闪烁体的衰减时间差异,Si-PM是否可用于深度交互(DOI)探测器仍不明确。为了弄清楚这一点,我们测试了滨松4×4 Si-PM阵列(S11065-025P)与使用不同衰减时间的闪烁体相结合,利用脉冲形状分析来开发DOI块状探测器。首先,将0.5 mol%铈掺杂的Gd₂SiO₅(GSO)闪烁体排列成4×4矩阵,并与Si-PM阵列每个像素的中心进行光学耦合,以测量能量分辨率及其随温度的增益变化。然后,将两种铈掺杂的Lu₁.₉Gd₀.₁SiO₅(LGSO)闪烁体,0.025 mol%铈(衰减时间:约31 ns)和0.75 mol%铈(衰减时间:约46 ns),在DOI方向上进行光学耦合,排列成11×7矩阵,并与Si-PM阵列进行光学耦合,以测试高分辨率DOI探测器的可能性。基于Si-PM阵列的GSO块状探测器对于Cs-137γ源(662 keV)的能量分辨率为18±4.4%半高宽(FWHM)。在LGSO DOI块状探测器的位置图中,小于1毫米的晶体清晰可辨。LGSO DOI块状探测器的脉冲形状谱得出的峰谷比(P/V)为2.2。这些结果证实,基于Si-PM阵列的DOI块状探测器对于高分辨率小动物PET系统很有前景。