Paul C. Lauterbur Research Centre for Biomedical Imaging, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China.
School of Nuclear Science and Technology, Lanzhou University, Lanzhou, 730030, China.
Med Phys. 2019 Apr;46(4):1608-1619. doi: 10.1002/mp.13432. Epub 2019 Feb 20.
High-sensitivity and high-resolution depth-encoding positron emission tomography (PET) detectors are required to simultaneously improve the sensitivity and spatial resolution of a PET scanner so that the quantitative accuracy of PET studies can be improved. The semi-monolithic scintillator PET detector has the advantage of measuring the depth of interaction with single-ended readout as compared to the traditional pixelated scintillator detector, and significantly reducing the edge effect that deteriorates the spatial resolution at edges of the detector as compared to the monolithic scintillator detector if a long rectangular semi-monolithic detector is used. In this work, depth-encoding PET detector modules were built by using long rectangular semi-monolithic scintillators and single-ended readout by silicon photomultiplier (SiPM) arrays. The performance of the detector modules was measured.
The rectangular semi-monolithic scintillator detector has an outside dimension of 11.6 × 37.6 × 10 mm and consists of 11 polished lutetium-yttrium oxyorthosilicate (LYSO) slices measuring 1 × 37.6 × 10 mm . The enhanced specular reflector (ESR) was glued on both cross-sectional surfaces of each crystal slice. For the face opposite to the SiPM array and the two end faces of the detectors, surface treatments with and without black paint were implemented for performance comparison. The bottom face of the semi-monolithic detector was coupled to a 4 × 12 SiPM array that was grouped along rows and columns separately into 16 signals. The four row signals were used to identify the slices, and the 12 column signals were used to estimate the y (monolithic direction) and z (depth direction) interaction positions. The detector was irradiated at multiple positions with a collimated 511 keV gamma beam. The collimated beam was obtained with electronic collimation by using a Na point source and a reference detector. The estimated width of the gamma beam is around 0.5 mm. The flood histogram for crystal slices was measured by using the center of gravity (COG) method. The COG method and the squared COG method were used for y position estimation. The standard deviation of the column signals, the ratio of maximum to the sum of the column signals, and the sum of squared column signals were used for z position estimation.
All slices were clearly resolved from the measured flood histograms for both detectors with different crystal surface treatments. The estimated y positions roughly linearly change with the true positions at the middle of the detector until ~5 mm from both ends of the detector. The y and z spatial resolutions of the detectors were estimated for all middle positions located more than 5 mm from both ends of the detector. The squared COG method provides better y position resolution than the COG method. The three z estimation methods provide similar depth of interaction (DOI) resolution. Surface treatment with black paint significantly improves both y and z position resolution but degrades the energy and timing resolution of the detectors. The average full width half maxima (FWHM) spatial resolution is improved from 1.77 to 1.07 mm in the y direction by using the squared COG method and from 2.71 to 1.55 mm in the z direction by using the standard deviation method. The slice-based average energy resolution degrades from 15.8% to 24.9%. The timing resolution of the entire detector module degrades from 596 to 788 ps.
The performance of rectangular semi-monolithic scintillator PET detectors with two different crystal surface treatments was measured. The detectors provide superior spatial resolution and depth-encoding capability and can be used to develop small animal and dedicated breast and brain PET scanners that can simultaneously achieve high spatial resolution, high sensitivity, and low cost.
高灵敏度和高分辨率深度编码正电子发射断层扫描(PET)探测器对于同时提高 PET 扫描仪的灵敏度和空间分辨率是必需的,以便提高 PET 研究的定量准确性。与传统的像素化闪烁体探测器相比,半单片闪烁体 PET 探测器具有通过单端读出测量相互作用深度的优势,如果使用长矩形半单片探测器,则与单片闪烁体探测器相比,还可以显著降低探测器边缘的边缘效应,从而降低空间分辨率。在这项工作中,使用长矩形半单片闪烁体和硅光电倍增管(SiPM)阵列进行了深度编码 PET 探测器模块的构建,并对探测器模块的性能进行了测量。
矩形半单片闪烁体探测器的外部尺寸为 11.6×37.6×10mm,由 11 个抛光的硅酸镥钇(LYSO)切片组成,尺寸为 1×37.6×10mm。在每个晶体切片的两个横截面表面都涂有增强镜面反射器(ESR)。对于与 SiPM 阵列相对的表面和探测器的两个端面,实施了有和没有黑色油漆的表面处理,以进行性能比较。半单片探测器的底面与一个 4×12 的 SiPM 阵列耦合,该阵列沿着行和列分别分为 16 个信号。四个行信号用于识别切片,12 个列信号用于估计 y(单片方向)和 z(深度方向)相互作用位置。探测器在多个位置用准直的 511keV 伽马射线束进行辐照。准直束通过使用 Na 点源和参考探测器进行电子准直获得。估计伽马射线束的宽度约为 0.5mm。使用重心(COG)方法测量晶体切片的洪水直方图。使用 COG 方法和平方 COG 方法进行 y 位置估计。列信号的标准偏差、列信号的最大值与和的比值以及列信号的平方和用于 z 位置估计。
对于具有不同晶体表面处理的两个探测器,从测量的洪水直方图中都可以清楚地分辨出所有切片。估计的 y 位置在探测器中间位置大致呈线性变化,直到探测器两端约 5mm 处。对于位于探测器两端 5mm 以上的所有中间位置,估计了探测器的 y 和 z 空间分辨率。平方 COG 方法提供比 COG 方法更好的 y 位置分辨率。三种 z 估计方法提供了相似的相互作用深度(DOI)分辨率。用黑色油漆进行表面处理可显著提高 y 和 z 位置分辨率,但会降低探测器的能量和定时分辨率。使用平方 COG 方法将 y 方向的全宽半最大值(FWHM)空间分辨率从 1.77 提高到 1.07mm,使用标准偏差方法将 z 方向的空间分辨率从 2.71 提高到 1.55mm。基于切片的平均能量分辨率从 15.8%下降到 24.9%。整个探测器模块的定时分辨率从 596 下降到 788ps。
测量了两种不同晶体表面处理的矩形半单片闪烁体 PET 探测器的性能。这些探测器提供了卓越的空间分辨率和深度编码能力,可用于开发小动物和专用乳房和脑部 PET 扫描仪,这些扫描仪可以同时实现高空间分辨率、高灵敏度和低成本。