补体在抗中性粒细胞胞质抗体相关性血管炎的发病机制中至关重要。

Complement is crucial in the pathogenesis of ANCA-associated vasculitis.

机构信息

Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

出版信息

Kidney Int. 2013 Jan;83(1):16-8. doi: 10.1038/ki.2012.371.

DOI:10.1038/ki.2012.371

PMID:23271485

Abstract

Renal lesions in ANCA-associated vasculitis (AAV) show an absence or paucity of immune deposits. Therefore, complement was not considered a major pathogenic factor. Data from an animal model of AAV, however, suggest involvement of the alternative pathway of complement. The paper by Gou et al. demonstrates activation also of the alternative and final common pathways in patients with AAV. Thus, the complement system might be a target for treatment in human AAV.

摘要

在抗中性粒细胞胞浆抗体（ANCA）相关性血管炎（AAV）中，肾脏病变表现为免疫沉积物的缺乏或减少。因此，补体被认为不是主要的致病因素。然而，来自 AAV 动物模型的数据表明，替代途径的补体参与其中。 Gou 等人的论文表明，AAV 患者的替代途径和最终共同途径也被激活。因此，补体系统可能是治疗人类 AAV 的靶点。