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羊膜带综合征或ADAM序列的流行病学及危险因素

Epidemiology and risk factors of amniotic band syndrome, or ADAM sequence.

作者信息

Cignini Pietro, Giorlandino Claudio, Padula Francesco, Dugo Nella, Cafà Ester Valentina, Spata Anna

机构信息

Department of Prenatal Diagnosis, Artemisia Fetal-Maternal Medical Center, Rome, Italy.

出版信息

J Prenat Med. 2012 Oct;6(4):59-63.

PMID:23272276
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3530965/
Abstract

Amniotic band sequence (ABS) is the term applied to a wide range of congenital anomalies, most typically limb and digital amputations and constriction rings, that occur in association with fibrous bands (1). These alterations may be associated or not with cutaneous and visceral abnormalities.This work, which is a literature review, examines several studies that relate to cases of amniotic band syndrome (SBA). In particular, our attention was focused on the causes and pathogenesis of the SBA. These for the most part are still unknown, but from what we observe in different jobs, are due to a mechanism of vascular damage. Therefore in this paper we examine chemical risk factors, like smoking, drug use, maternal hyperglycemia, mechanical risk factors such as the puncture of the amniotic sac after amniocentesis. We also speak of the altitude as a risk factor related to blood pressure, of the increased incidence of disease in primigravid, in women with a low level of education, in which the pregnancy was not planned, and then we talk of a higher incidence in young fathers and of the role of familiarity.

摘要

羊膜带序列(ABS)是用于描述一系列先天性异常的术语,最典型的是肢体和手指截肢以及缩窄环,这些异常与纤维带相关联(1)。这些改变可能与皮肤和内脏异常有关,也可能无关。这项文献综述工作研究了几项与羊膜带综合征(SBA)病例相关的研究。特别是,我们的注意力集中在SBA的病因和发病机制上。这些在很大程度上仍然未知,但从我们在不同研究中观察到的情况来看,是由于血管损伤机制。因此,在本文中我们研究了化学风险因素,如吸烟、药物使用、母亲高血糖,机械风险因素如羊膜穿刺术后羊膜囊的穿刺。我们还提到海拔作为与血压相关的风险因素,初产妇、未计划怀孕的低教育水平女性中疾病发病率的增加,然后我们谈到年轻父亲中较高的发病率以及家族性的作用。

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本文引用的文献

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Maternal dietary glycaemic intake during pregnancy and the risk of birth defects.孕期母体血糖摄入与出生缺陷风险。
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