Division of Epidemiology, Statistics and Prevention Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.
Matern Child Health J. 2012 Feb;16(2):385-92. doi: 10.1007/s10995-011-0759-z.
This study examined the association between paternal age and a wide range of structural birth defects. Data were drawn from The California Birth Defects Monitoring Program, a population-based active surveillance system for collecting information on infants and fetuses with defects born between 1989 and 2002. The analysis included 46,114 cases with defects, plus a random sample of 36,838 non-malformed births. After adjustment for maternal age, risks of anomalies of the nervous system for 38 and 42 year-old fathers, as compared to 29 year-old fathers, were 1.05-fold [1.00, 1.11] and 1.10-fold [1.02, 1.18] higher, respectively. Similar results were observed for anomalies of the limbs, where 38 and 42 year-old fathers had a 1.06-fold [1.02, 1.11] and 1.11-fold [1.05, 1.18] higher risk, respectively. Risks of anomalies of the integument were 1.05-fold [1.00, 1.09] and 1.10-fold [1.03, 1.16] higher for 38 and 42 year olds, respectively. Young paternal age, i.e., less than 29 years, was associated with an increased risk of amniotic bands (OR: 0.87 [0.78, 0.97]), pyloric stenosis (OR: 0.93 [0.90, 0.96]) and anomalies of the great veins (OR: 0.93 [0.87, 1.00]). In sum, both advanced and young paternal age was associated with select birth defects in California between 1989 and 2002.
这项研究考察了父亲年龄与广泛的结构出生缺陷之间的关联。数据来自加利福尼亚出生缺陷监测计划，这是一个基于人群的主动监测系统，用于收集 1989 年至 2002 年间出生的有缺陷婴儿和胎儿的信息。该分析包括 46114 例缺陷病例，以及 36838 例非畸形出生的随机样本。在调整母亲年龄后，与 29 岁父亲相比，38 岁和 42 岁父亲的神经系统异常风险分别高出 1.05 倍[1.00，1.11]和 1.10 倍[1.02，1.18]。四肢异常也观察到类似的结果，38 岁和 42 岁的父亲风险分别高出 1.06 倍[1.02，1.11]和 1.11 倍[1.05，1.18]。38 岁和 42 岁父亲的皮肤异常风险分别高出 1.05 倍[1.00，1.09]和 1.10 倍[1.03，1.16]。年轻的父亲年龄，即小于 29 岁，与羊膜带异常（OR：0.87[0.78，0.97]）、幽门狭窄（OR：0.93[0.90，0.96]）和大静脉异常（OR：0.93[0.87，1.00]）的风险增加有关。总之，1989 年至 2002 年间，加利福尼亚州的先进和年轻父亲年龄都与某些出生缺陷有关。
