Kumar A, Sharma B, Pandey R S
Biochemistry Laboratory, Department of Zoology, University of Allahabad, Allahabad-211002, India.
Cell Mol Biol (Noisy-le-grand). 2012 Dec 22;58(1):153-9.
The present study was planned to see the changes in the levels of different biochemical stress markers such as the level of lipid peroxidation and the specific activities of lactate dehydrogenase (LDH), acid and alkaline phosphatases in different organs such as brain, liver, kidney, gills and muscle of a freshwater muddy fish, Channa punctatus in effect to pyrethroid insecticides, cypermethrin and λ-cyhalothrin treated for 96 h. The results showed significant increase in the levels of lipid peroxidation as well as the activities of LDH, acid and alkaline phosphatases in a dose dependent manner. The remarkable increase in the levels of these stress biomarkers indicates strong stress inducing potential of these insecticides in fishes. The importance of the current study lies in indicating the potential risk of muddy freshwater fishes due to strong soil binding property of pyrethroids along with their slow metabolism in fishes as compared to that of mammals.
本研究旨在观察淡水泥鱼斑鳢的脑、肝、肾、鳃和肌肉等不同器官中脂质过氧化水平以及乳酸脱氢酶(LDH)、酸性和碱性磷酸酶的比活性等不同生化应激标志物水平在拟除虫菊酯类杀虫剂氯氰菊酯和高效氯氟氰菊酯处理96小时后的变化。结果显示,脂质过氧化水平以及LDH、酸性和碱性磷酸酶的活性呈剂量依赖性显著增加。这些应激生物标志物水平的显著升高表明这些杀虫剂对鱼类具有很强的应激诱导潜力。本研究的重要性在于表明,由于拟除虫菊酯类化合物具有很强的土壤结合特性,且与哺乳动物相比,它们在鱼类体内的代谢缓慢,因此淡水泥鱼存在潜在风险。