International Agency for Research on Cancer (IARC-WHO), Lyon, France. nep.iarc.fr
Ann Epidemiol. 2013 Feb;23(2):93-8. doi: 10.1016/j.annepidem.2012.11.009. Epub 2012 Dec 25.
Alcohol intake may adversely affect the concentrations of endogenous sex hormones, and thus increase the risk of endometrial cancer. However, epidemiologic studies have provided conflicting results. Therefore, we investigated the association between alcohol intake and endometrial cancer risk a large, multicenter, prospective study.
From 1992 through 2010, 301,051 women in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort were followed for incident endometrial cancer (n = 1382). Baseline alcohol consumption was assessed by country-specific, validated dietary questionnaires. Information on past alcohol consumption was collected by lifestyle questionnaires. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated from Cox proportional hazard models.
The multivariable HRs (and 95% CIs) compared with light drinkers (0.1-6 g/d) were 1.03 (0.88-1.20) for 0 g of alcohol per day at baseline, 1.01 (0.86-1.17) for 6.1-12 g/d, 1.03 (0.87-1.22) for 12.1-24 g/d, 1.07 (0.87-1.38) for 24.1-36 g/d, and 0.85 (0.61-1.18) for more than 36 g/d (p(trend) = 0.77). No association was observed among former drinkers (OR, 1.28; 95% CI, 0.98-1.68 compared with light drinkers). Null associations were also found between alcohol consumption at age 20 years, lifetime pattern of alcohol drinking, and baseline alcohol intake from specific alcoholic beverages and endometrial cancer risk.
Our findings suggest no association between alcohol intake and endometrial cancer risk.
饮酒可能会影响内源性性激素的浓度，从而增加子宫内膜癌的风险。然而，流行病学研究的结果并不一致。因此，我们开展了一项大型多中心前瞻性研究，旨在调查饮酒与子宫内膜癌风险之间的关联。
1992 年至 2010 年，欧洲癌症与营养前瞻性调查（EPIC）队列中的 301051 名女性（n=1382）参与了本研究，随访期间发生子宫内膜癌。采用特定国家验证的饮食问卷评估基线饮酒量。通过生活方式问卷收集过去饮酒量的信息。使用 Cox 比例风险模型估计风险比（HR）和 95%置信区间（CI）。
多变量 HR（95%CI）与轻饮酒者（0.1-6 g/d）相比，基线时每天酒精摄入量为 0 克为 1.03（0.88-1.20），6.1-12 g/d 为 1.01（0.86-1.17），12.1-24 g/d 为 1.03（0.87-1.22），24.1-36 g/d 为 1.07（0.87-1.38），36 克/天以上为 0.85（0.61-1.18）（p(trend)=0.77）。与轻饮酒者相比，前饮酒者（OR，1.28；95%CI，0.98-1.68）的风险没有差异。在 20 岁时的饮酒量、终生饮酒模式以及特定酒精饮料的基线饮酒量与子宫内膜癌风险之间也未发现关联。
我们的研究结果表明，饮酒与子宫内膜癌风险之间无关联。
