Department of Microbiology, Hallym University, Chuncheon 200-702, Republic of Korea.
J Microbiol. 2012 Dec;50(6):1067-70. doi: 10.1007/s12275-012-2541-3. Epub 2012 Dec 30.
During the 2009-2011 influenza seasons, 10.26% of the specimens isolated from patients in South Korea were subtyped as H3N2 viruses. Some oseltamivir-sensitive H3N2 samples exhibited different plaque morphologies, and were found to have novel mutations in the neuraminidase gene. In a subsequent analysis using NA mutant viruses, viral compensation against oseltamivir treatment was observed only in the N2 mutant virus. All things considered, these novel mutations may account for the exclusive characteristics of selected H3N2 viruses observed in plaque reduction assays.
在 2009-2011 年流感季节期间，从韩国患者中分离的样本中，有 10.26%被亚型化为 H3N2 病毒。一些奥司他韦敏感的 H3N2 样本表现出不同的蚀斑形态，并且在神经氨酸酶基因中发现了新的突变。在随后使用 NA 突变病毒的分析中，仅在 N2 突变病毒中观察到针对奥司他韦治疗的病毒补偿。综上所述，这些新的突变可能是在蚀斑减少试验中观察到的特定 H3N2 病毒的独特特征的原因。
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