Latent infection by herpes simplex virus.

The experimental evidence contributing to the understanding of herpes simplex virus latent infection has been reviewed. The site of residence of the virus during silent periods of the disease appears to be, in the majority of instances, the sensory ganglion innervating the territory of prime infection. Little is known about the factors that bring about latent infection, maintain it, and regulate the production of infectious particles that cause recurrences.