Convery M, McCarthy G F, Brawer J R
Department of Anatomy, McGill University, Montreal, Canada.
Anat Rec. 1990 Mar;226(3):328-36. doi: 10.1002/ar.1092260309.
The estradiol valerate-induced polycystic ovarian condition in the rat represents a normal ovarian response to aberrant endocrine stimuli. Although we have shown that removal of one polycystic ovary (hemiovariectomy) results in restoration of cyclicity and normal morphology in the remaining ovary by 1 week, nothing is known about the process of recovery or about the role of the hypothalamo-pituitary unit in initiating recovery. We have therefore examined ovaries at 3, 12, 24, 48, and 120 hours following removal of the contralateral polycystic ovaries. The ovarian content and size distribution of healthy and atretic follicles was determined, as well as the occurrence of follicular cysts, type III large follicular structures, and corpora lutea. The plasma LH pattern was also examined at a short postoperative interval. At 3 hours, there was a significant increase in mean ovarian weight that coincided with the emergence of healthy large secondary follicles. By 12 hours, there was a significant sustained diminution in the number of atretic follicles of all sizes, but the total number of healthy follicles did not increase significantly until 120 hours. The cystic follicles had all but disappeared by 120 hours because of mechanical compression by newly developing ovarian tissue. Ovarian recovery is, therefore, biphasic, consisting of a very early diminution in atresia coincident with, and perhaps caused by, a major alteration in the plasma LH pattern. The second phase is characterized by a wave of follicular recruitment and development.
戊酸雌二醇诱导的大鼠多囊卵巢状态代表了卵巢对异常内分泌刺激的正常反应。尽管我们已经表明切除一侧多囊卵巢（半卵巢切除术）会导致剩余卵巢在1周内恢复周期性和正常形态，但对于恢复过程以及下丘脑 - 垂体单位在启动恢复中的作用却一无所知。因此，我们在切除对侧多囊卵巢后的3、12、24、48和120小时检查了卵巢。确定了健康卵泡和闭锁卵泡的卵巢含量及大小分布，以及卵泡囊肿、III型大卵泡结构和黄体的出现情况。术后短时间内还检查了血浆促黄体生成素（LH）模式。3小时时，平均卵巢重量显著增加，这与健康大次级卵泡的出现同时发生。到12小时时，各种大小的闭锁卵泡数量持续显著减少，但直到120小时健康卵泡总数才显著增加。由于新发育的卵巢组织的机械压迫，囊性卵泡在120小时时几乎全部消失。因此，卵巢恢复是双相的，包括早期闭锁的显著减少，这与血浆LH模式的重大改变同时发生，并且可能是由其引起的。第二阶段的特征是卵泡募集和发育的浪潮。
