Farookhi R, Hemmings R, Brawer J R
Biol Reprod. 1985 Apr;32(3):530-40. doi: 10.1095/biolreprod32.3.530.
An acyclic polycystic ovarian condition can be induced in adult rats with a single injection of estradiol valerate (EV). The ovaries are small and contain multiple cystic follicles and no new corpora lutea. In the early stages of the condition, both basal plasma luteinizing hormone (LH) and LH responses to luteinizing hormone-releasing hormone (LHRH) are attenuated. Plasma androgens are indistinguishable from normal controls. The present study examines the effect of unilateral ovariectomy (ULO) on this condition. Removal of one cystic ovary results in almost immediate resumption of vaginal cyclicity that persists for at least 3 wk. At 1 or 3 wk after ULO the remaining ovary contains fresh corpora lutea, appears histologically normal, and is significantly heavier than the cystic ovary removed at ULO, indicative of compensatory hypertrophy. Despite the resumption of apparently normal cyclic function, basal plasma LH concentrations and LH responses to LHRH are not significantly better than those in intact animals with polycystic ovaries. Thus, the previously polycystic ovary is fully capable of normal ovulatory function despite obvious impairments in the hypothalamo-pituitary axis. Since ovulatory function resumes on a background of continued poor pituitary responsiveness, the primary defect, which ULO corrects, is probably at the hypothalamic level. Finally, the cystic ovary clearly contributes to the hypothalamic aberration to which it subsequently responds.
单次注射戊酸雌二醇（EV）可在成年大鼠中诱发一种无周期性的多囊卵巢状况。卵巢体积小，含有多个囊性卵泡，且无新的黄体。在该状况的早期阶段，基础血浆促黄体生成素（LH）以及LH对促黄体生成素释放激素（LHRH）的反应均减弱。血浆雄激素水平与正常对照组无差异。本研究考察了单侧卵巢切除术（ULO）对这种状况的影响。切除一侧囊性卵巢后，阴道周期几乎立即恢复，并持续至少3周。ULO术后1周或3周时，剩余卵巢含有新鲜黄体，组织学上看似正常，且明显比ULO时切除的囊性卵巢重，表明存在代偿性肥大。尽管恢复了明显正常的周期功能，但基础血浆LH浓度以及LH对LHRH的反应并不比患有多囊卵巢的完整动物显著更好。因此，尽管下丘脑 - 垂体轴存在明显损伤，但先前的多囊卵巢仍完全具备正常排卵功能。由于排卵功能在垂体反应持续不佳的背景下恢复，ULO所纠正的主要缺陷可能位于下丘脑水平。最后，囊性卵巢显然促成了随后它所响应的下丘脑异常。
