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实施英国国家卫生与临床优化研究所关于静脉血栓栓塞风险评估的指南:失败、成功与争议

Implementing NICE guidelines on risk assessment for venous thromboembolism: failure, success and controversy.

作者信息

Thavarajah Dushan, Wetherill Martin

机构信息

Department of Trauma and Orthopaedics, The Royal Berkshire Hospital, Reading, UK.

出版信息

Int J Health Care Qual Assur. 2012;25(7):618-24. doi: 10.1108/09526861211261217.

Abstract

PURPOSE

Venous thromboembolism (VTE) prophylaxis guidelines were originally published by the National Institute of Clinical Excellence (NICE) in April 2007. Controversy eclipsed their release. Consequently, the VTE prophylaxis publication was reviewed and republished in January 2010. The NICE guidelines recommend that all patients are assessed for risk before pharmacological prophylaxis is offered and reassessed at 24 hours to check adverse reactions; and that prophylaxis is appropriate. This paper aims to look at their implementation.

DESIGN/METHODOLOGY/APPROACH: A prospective audit and re-audit in one orthopaedic department was completed to see how well the new guidelines were adhered to, find out first-hand what problems there were, and how they might be remedied.

FINDINGS

Audit and re-audit highlighted that attaching an assessment tool to drug charts is plausible.

RESEARCH LIMITATIONS/IMPLICATIONS: The study was limited to one centre and used a relatively weak research design.

PRACTICAL IMPLICATIONS

As a process, the clinical impact of risk assessment for VTE is questionable as many patients will be high risk. Removing reassessment at 24 hours from the NICE guidance is recommended.

ORIGINALITY/VALUE: The authors put the NICE guideline into clinical practice, demonstrating how effectively it can work with their method, but also highlighting its flaws.

摘要

目的

静脉血栓栓塞症(VTE)预防指南最初由英国国家卫生与临床优化研究所(NICE)于2007年4月发布。其发布引发了争议。因此,VTE预防指南在2010年1月进行了审查并重新发布。NICE指南建议,在提供药物预防之前,应对所有患者进行风险评估,并在24小时后重新评估以检查不良反应;且预防措施应适当。本文旨在探讨这些指南的实施情况。

设计/方法/途径:在一个骨科部门完成了一项前瞻性审核和重新审核,以了解新指南的遵循情况,直接找出存在的问题以及如何解决这些问题。

研究结果

审核和重新审核强调在药物图表上附上评估工具是可行的。

研究局限性/影响:该研究仅限于一个中心,且采用了相对较弱的研究设计。

实际意义

作为一个过程,VTE风险评估的临床影响值得怀疑,因为许多患者将属于高风险。建议从NICE指南中删除24小时重新评估这一要求。

原创性/价值:作者将NICE指南应用于临床实践,展示了其方法的有效性,但也突出了其缺陷。

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