水扩张联合膀胱训练与单纯水扩张治疗间质性膀胱炎的比较。
Hydrodistention plus bladder training versus hydrodistention for the treatment of interstitial cystitis.
机构信息
Department of Obstetrics and Gynecology, Clinic of Fu Jen Catholic University, Taipei, Taiwan.
出版信息
Taiwan J Obstet Gynecol. 2012 Dec;51(4):591-5. doi: 10.1016/j.tjog.2012.11.001.
OBJECTIVE
To assess the efficacy of hydrodistention (HD) followed by bladder training (BT) versus HD alone in patients with interstitial cystitis (IC).
METHODS
A total of 70 patients with IC were included and randomly assigned to two groups: one treated with HD (HD group) and the other treated with HD plus BT (HD plus BT group). Each patient was followed up using a weekly diary for 8 weeks after HD and monthly thereafter for 6 months after HD. Evaluation parameters included age, duration of IC in years, how many doctors visited before treatment, urgency, bladder pain, daytime voided volume per void, nocturnal volume per void, daytime voids per day, and nocturia per day.
RESULTS
Age, duration of IC in years, doctors visited before treatment, and voiding profiles of patients before treatments between the two groups did not show statistical significance. However, at 24 weeks after HD, the proportions of urgency, and bladder pain of the HD group versus the HD plus BT group were 43.48% versus 10.71% (p = 0.008), and 34.78% versus 14.29% (p = 0.086), respectively. Concurrently, the mean ± standard deviation of daytime voided volume per void, nocturnal volume per void, daytime voids per day, and nocturia per day of the HD group and HD plus BT group are 212.2 ± 114.2 mL and 300.1 ± 90.2 mL (p = 0.005), 276.8 ± 113.0 mL and 360.0 ± 129.6 mL (p = 0.018), 8.2 ± 3.2 and 6.2 ± 1.4 (p = 0.010), and 2.2 ± 1.2 and 1.5 ± 0.7 (p = 0.019), respectively.
CONCLUSION
HD followed by BT produced a statistically significantly better effect than HD alone in the treatment of patients with IC.
目的
评估水扩张（HD）联合膀胱训练（BT）与单纯 HD 治疗间质性膀胱炎（IC）的疗效。
方法
纳入 70 例 IC 患者，随机分为两组：HD 治疗组（HD 组）和 HD 联合 BT 治疗组（HD 联合 BT 组）。HD 后每周随访 1 次，共 8 周，之后每月随访 1 次，共 6 个月。评估参数包括年龄、IC 病程、治疗前就诊医生数、尿急、膀胱疼痛、每次排尿日间尿量、每次排尿夜间尿量、每日排尿次数和每日夜尿次数。
结果
两组患者年龄、IC 病程、治疗前就诊医生数和治疗前排尿情况无统计学差异。然而，HD 后 24 周时，HD 组尿急和膀胱疼痛的比例分别为 43.48%和 10.71%（p = 0.008），34.78%和 14.29%（p = 0.086），而 HD 组和 HD 联合 BT 组的日间排尿量、夜间排尿量、每日排尿次数和每日夜尿次数的均值 ± 标准差分别为 212.2 ± 114.2 mL 和 300.1 ± 90.2 mL（p = 0.005），276.8 ± 113.0 mL 和 360.0 ± 129.6 mL（p = 0.018），8.2 ± 3.2 和 6.2 ± 1.4（p = 0.010），2.2 ± 1.2 和 1.5 ± 0.7（p = 0.019）。
结论
HD 联合 BT 治疗 IC 患者的疗效明显优于单纯 HD。
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