Ruiz Soler J G, Fernández Navarro J M, Verdeguer Miralles A, Esquembre Menor C, Ferris Tortajada J, Castel Sánchez V
Unidad de Oncologia Pediátrica del Hospital Infantil La Fe, Valencia.
An Esp Pediatr. 1990 Jan;32(1):58-62.
Twenty-one children, between eight months and twelve years old, diagnosed as having acute nonlymphoblastic leukemia (ANLL), were treated with an intensive chemotherapy based on a modified VAPA protocol. Complete remission rate was 80%, and the 5 year-survival rate is 46%. One chloroma, one central nervous system, and four bone marrow relapses were observed; all except the first having an unfavourable outcome. Significant risk prognostic factors in this series proved to be hepatomegaly (greater than 5 cm) and delay in obtaining remission. No fatal complications were observed.
21名年龄在8个月至12岁之间、被诊断为急性非淋巴细胞白血病（ANLL）的儿童，接受了基于改良VAPA方案的强化化疗。完全缓解率为80%，5年生存率为46%。观察到1例绿色瘤、1例中枢神经系统和4例骨髓复发；除第一例外，其余均预后不良。该系列中显著的风险预后因素为肝肿大（大于5厘米）和缓解延迟。未观察到致命并发症。
