Department of Psychiatry, Chonnam National University Medical School, and Depression Clinical Research Center, Chonnam National University Hospital, Gwangju, Republic of Korea.
J Affect Disord. 2013 May 15;148(1):57-65. doi: 10.1016/j.jad.2012.11.048. Epub 2012 Dec 29.
Since inflammatory cytokines have been implicated in the pathophysiology of both cancer and depression, genes that contribute to determining cytokine functional activity are reasonable candidate risk factors for depression related to cancer. This study aimed to investigate whether alleles related to higher pro-inflammatory and/or lower anti-inflammatory cytokine production would associate with depression in a cohort with breast cancer.
A total of 309 women with breast cancer were evaluated one week after surgery, and 244 (79%) were followed one year later. Depression (major+minor depressive disorders) was diagnosed according to DSM-IV criteria using the Mini International Neuropsychiatric Interview on both occasions. Six pro-(TNF-α-850C/T and -308G/A, IL-1β-511C/T and +3953C/T, IL-6-174G/C, IL-8-251T/A) and two anti-inflammatory (IL-4 +33T/C, IL-10-1082G/A) cytokine polymorphisms were assayed, and total numbers of potential risk alleles were calculated for pro- and anti-inflammatory cytokine genes. Adjustments were made for demographic and clinical characteristics.
At baseline, 74 (24%) patients were classified with prevalent depression; and at follow-up, 19 (8%) and 25 (10%) patients were classified with persistent and incident depression, respectively. A higher number of pro-inflammatory cytokine risk alleles, and IL-1β-511T/T genotype individually, were independently associated with both prevalent depression at baseline and persistent depression at one year follow-up.
Sample size was relatively small.
Our findings support the role of pro-inflammatory cytokines in the etiology of depression related to breast cancer, and provide novel evidence of a potential genetic basis for this.
由于炎性细胞因子与癌症和抑郁症的病理生理学都有关联，因此决定细胞因子功能活性的基因是与癌症相关的抑郁症的合理候选风险因素。本研究旨在探讨与更高的促炎性和/或更低的抗炎性细胞因子产生相关的等位基因是否与乳腺癌患者中的抑郁症相关。
总共评估了 309 名乳腺癌女性，在手术后一周进行评估，其中 244 名（79％）在一年后进行了随访。两次均根据 DSM-IV 标准，使用 Mini 国际神经精神访谈进行抑郁（主要+轻度抑郁障碍）的诊断。共检测了 6 种促炎性（TNF-α-850C/T 和 -308G/A、IL-1β-511C/T 和 +3953C/T、IL-6-174G/C、IL-8-251T/A）和 2 种抗炎性（IL-4 +33T/C、IL-10-1082G/A）细胞因子多态性，为促炎性和抗炎性细胞因子基因计算潜在的风险等位基因总数。根据人口统计学和临床特征进行了调整。
基线时，74 名（24％）患者被归类为患有现患抑郁症；随访时，19 名（8％）和 25 名（10％）患者分别被归类为持续性和新发抑郁症。较高数量的促炎性细胞因子风险等位基因，以及单独的 IL-1β-511T/T 基因型，与基线时现患抑郁症和一年随访时持续性抑郁症均独立相关。
样本量相对较小。
我们的研究结果支持促炎性细胞因子在与乳腺癌相关的抑郁症发病机制中的作用，并为这一机制提供了潜在遗传基础的新证据。
