Bartels P C, Helleman P W, Soons J B
Department of Clinical Chemistry and Haematology, Medical Centre, Alkmaar, The Netherlands.
Ann Clin Biochem. 1990 Mar;27 ( Pt 2):102-6. doi: 10.1177/000456329002700202.
A longitudinal investigation of changes in red blood cell (RBC) size distribution and zinc protoporphyrin/haemoglobin (ZPP/Hb) ratio was performed. In the course of the first few weeks after birth RBC size distribution histograms show a loss of macrocytic RBCs demonstrated by a rapid decrease of the fraction of macrocytes, whereas the degree of RBC volume dispersion decreases simultaneously. Within this period a significant change in the fraction of microcytes was not observed. At about 6 months of age, a marked shift of RBC size distribution histograms towards lower volumes occurs. Concomitant with the lower MCV values, the values for the absolute distribution width at half peak height (ADW0.5) also showed an obvious decrease. At birth, ZPP/Hb ratios are about three times higher than those of adult subjects and decrease slowly during infancy. This suggests that iron deficiency is unlikely in the first months of life.
对红细胞（RBC）大小分布和锌原卟啉/血红蛋白（ZPP/Hb）比值的变化进行了纵向研究。在出生后的最初几周内，红细胞大小分布直方图显示大红细胞减少，表现为大红细胞比例迅速下降，而红细胞体积离散度同时降低。在此期间，未观察到小红细胞比例的显著变化。在大约6个月大时，红细胞大小分布直方图明显向更低体积偏移。与较低的平均红细胞体积（MCV）值相伴，半峰高处绝对分布宽度（ADW0.5）的值也明显降低。出生时，ZPP/Hb比值约为成人的三倍，并在婴儿期缓慢下降。这表明在生命的最初几个月不太可能缺铁。
