Seo Jae-Hyun, Kang Jun-Myung, Lee HeeJeong, Lee WeonSun, Hwang Se-Hwan, Joo Young-Hoon
Department of Otolaryngology, Head and Neck Surgery, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Int J Pediatr Otorhinolaryngol. 2013 Mar;77(3):429-33. doi: 10.1016/j.ijporl.2012.12.003. Epub 2012 Dec 29.
Limited information is available regarding the characteristics of histiocytic necrotizing lymphadenitis (HNL) in children. This study compares the clinical and laboratory features as well as the immunohistochemical findings of HNL in children with those of adults.
Retrospective analysis.
Thirty patients who underwent a biopsy of a cervical lymph node and were histologically proven to have HNL were enrolled in this study. There were 13 children and 17 adults. CD68, CD163 and myeloperoxidase expression were analyzed by immunohistochemical staining.
Children had more bilateral lymphadenopathy (P=0.045) and a higher expression of CD68 (P=0.043) than did the adult patients. However, there was no significant difference between the groups in the following variables: patient gender, presence of fever, size and necrosis of enlarged lymph node, multiplicity of lymphadenopathy, WBC count, ESR, CRP, recurrence, and expression of myeloperoxidase and CD163.
The clinical and immunohistological characteristics of HNL in pediatric patients are similar to those of adults. Bilateral involvement of lymph nodes and a high expression of CD68 were the only features significantly associated with children with HNL.
关于儿童组织细胞坏死性淋巴结炎（HNL）的特征，现有信息有限。本研究比较了儿童与成人HNL的临床和实验室特征以及免疫组化结果。
回顾性分析。
本研究纳入了30例经颈部淋巴结活检组织学证实为HNL的患者。其中儿童13例，成人17例。通过免疫组化染色分析CD68、CD163和髓过氧化物酶的表达。
与成年患者相比，儿童双侧淋巴结病更多（P = 0.045），CD68表达更高（P = 0.043）。然而，在以下变量方面，两组之间无显著差异：患者性别、发热情况、肿大淋巴结的大小和坏死情况、淋巴结病的多发性、白细胞计数、血沉、C反应蛋白、复发情况以及髓过氧化物酶和CD163的表达。
儿童患者HNL的临床和免疫组织学特征与成人相似。双侧淋巴结受累和CD68高表达是与儿童HNL显著相关的唯一特征。
