Xu Li-qin, Han Yong-mei, Li Yong-wei, Sun De-ben
The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China.
Zhonghua Nei Ke Za Zhi. 2006 Feb;45(2):127-9.
To study the clinical manifestation and pathological features of histiocytic necrotizing lymphadenitis (Kikuchi's disease, KD).
52 patients with KD were collected to analyze the clinical manifestation, pathological features of biopsy lymph nodes, diagnosis and treatment.
41 cases (79%) were female of the 52 patients. The main clinical features included persistent fever (100%), single (23%)/multi (77%)-lymphadenopathy (always in cervical region), pleomorphism erythra (35%), neutropenia (76%), elevated erythrocyte sedimentation rate (100%), insensitivity to antibiotics (100%) and sensitivity to small dosage glucocorticoid (81%). 26 cases (50%) had elevated aspartate aminotransferase and/or alanine aminotransferase, but only 7 cases (13%) had upper respiratory tract symptom like influenza. Pathological features included distinctive necrosis, loss of lymph node structure, infiltration with histiocytes and lymphocytes, absence of neutrophils. Immunohistochemical stainings showed CD(68) positive for histiocytes and CD(3), CD(45) RO positive for T lymphocytes.
Diagnosis of KD relies on the pathological examination and immunohistochemical staining.
研究组织细胞坏死性淋巴结炎（菊池病，KD）的临床表现及病理特征。
收集52例KD患者，分析其临床表现、活检淋巴结的病理特征、诊断及治疗情况。
52例患者中41例（79%）为女性。主要临床特征包括持续发热（100%）、单发（23%）/多发（77%）淋巴结病（均位于颈部）、多形性红斑（35%）、中性粒细胞减少（76%）、血沉升高（100%）、对抗生素不敏感（100%）及对小剂量糖皮质激素敏感（81%）。26例（50%）天门冬氨酸氨基转移酶和/或丙氨酸氨基转移酶升高，但仅有7例（13%）有类似流感的上呼吸道症状。病理特征包括特征性坏死、淋巴结结构消失、组织细胞和淋巴细胞浸润、无中性粒细胞。免疫组化染色显示组织细胞CD(68)阳性，T淋巴细胞CD(3)、CD(45)RO阳性。
KD的诊断依赖于病理检查及免疫组化染色。
