Roger M, Nahoul K, Toublanc J E, Castanier M, Canlorbe P, Job J C
Sem Hop. 1979;55(39-40):1817-23.
Plasma testosterone, androstenedione, dehydroepiandrosterone and dehydroepiandrosterone-sulfate were measured by radioimmunoassay in 222 normal boys aged 1 hour to 18 years and 40 normal men aged 20 to 40 years. Three periods of high testosterone levels were observed in boys during extra-uterine life: first day (mean level 12 nmol/l), from the 12th to the 119th day (9 nmol/l) and from 13 years onwards in pubertal boys; the highest values were reached between 20 and 40 years (18 nmol/l). Androstenedione curve exhibited three coincident high concentrations phases: mean level at birth 8.7 nmol/l, and from 12th to 119th day 2.6 nmol/l. The lowest values were observed between 2 and 4 years; then a progressive increase occured up to adult age levels: 3.5 nmol/l. Dehydroepiandrosterone mean level was high at birth (20 nmol/l) then decreased slowly, either regularly or with a rebound during the 2nd month, a minimum being reached between 2 and 4 years (0.28 nmol/l). It increased thereafter exponentially up to adult levels reached after the age of 16 years (14 nmol/l). Dehydroepiandrosterone-sulfate mean level decreased regularly from birth to the second year, then its curve paralleled the dehydroepiandrosterone curve.
采用放射免疫分析法对222名年龄在1小时至18岁的正常男孩和40名年龄在20至40岁的正常男性测定血浆睾酮、雄烯二酮、脱氢表雄酮及硫酸脱氢表雄酮水平。在宫外生活期间观察到男孩有三个睾酮水平较高的时期：出生第一天（平均水平12纳摩尔/升）、第12天至第119天（9纳摩尔/升）以及13岁起的青春期男孩；最高值出现在20至40岁之间（18纳摩尔/升）。雄烯二酮曲线呈现出三个重合的高浓度阶段：出生时平均水平8.7纳摩尔/升，第12天至第119天为2.6纳摩尔/升。最低值出现在2至4岁之间；随后逐渐上升至成年水平：3.5纳摩尔/升。脱氢表雄酮出生时平均水平较高（20纳摩尔/升），然后缓慢下降，下降过程或呈规律性，或在第二个月出现反弹，在2至4岁时达到最低值（0.28纳摩尔/升）。此后呈指数上升直至16岁后达到成年水平（14纳摩尔/升）。硫酸脱氢表雄酮平均水平从出生到第二年呈规律性下降，然后其曲线与脱氢表雄酮曲线平行。
