Institute of Cardiovascular and Medical Sciences, University of Glasgow, G12 8QQ, Scotland, UK.
Heart Lung Circ. 2013 Apr;22(4):243-55. doi: 10.1016/j.hlc.2012.11.016. Epub 2012 Dec 29.
Acute myocardial infarction (AMI) is a leading cause of mortality and morbidity in the world, despite the rate having significantly declined over the past decade. The aim of this review is to consider the emerging diagnostic and clinical utility of cardiac MRI in patients with recent AMI. Cardiac MRI has high reproducibility and accuracy, allowing detailed functional assessment and characterisation of myocardial tissue. In addition to traditional measures including infarct size (IS), transmural extent of necrosis and microvascular obstruction (MVO), other infarct characteristics can now be identified using innovative MRI techniques. These novel pathologies include myocardial oedema and myocardial haemorrhage which also have functional and prognostic implications for patients. In addition to its diagnostic utility in ordinary clinical practice, cardiac MRI has been increasingly used to provide information on surrogate outcome measures, such as left ventricular ejection fraction (LVEF) and volumes, in clinical trials. MRI is becoming more available in secondary care, however, the potential clinical utility and cost effectiveness of MRI in post-MI patients remains uncertain. Cardiac MRI is most likely to be useful in high risk patients with risk factors for heart failure (HF). This includes individuals with early signs of pump failure and risk factors for adverse remodelling, such as MVO. This review focuses on the role of cardiac MRI in the assessment of patients with AMI.
急性心肌梗死(AMI)是世界上导致死亡和发病的主要原因,尽管在过去十年中其发病率显著下降。本综述旨在探讨心脏 MRI 在近期 AMI 患者中的新兴诊断和临床应用价值。心脏 MRI 具有高度的可重复性和准确性,可实现详细的功能评估和心肌组织特征分析。除了传统的测量指标,如梗死面积(IS)、坏死的透壁程度和微血管阻塞(MVO)外,现在还可以使用创新的 MRI 技术来识别其他梗死特征。这些新的病理特征包括心肌水肿和心肌出血,它们对患者的功能和预后都有影响。除了在普通临床实践中的诊断应用外,心脏 MRI 也越来越多地用于临床试验中提供替代终点指标(如左心室射血分数(LVEF)和容量)的信息。MRI 在二级医疗机构中越来越普及,但是心脏 MRI 在 MI 后患者中的潜在临床应用价值和成本效益仍不确定。心脏 MRI 最有可能对有心力衰竭(HF)风险因素的高危患者有用。这些患者包括早期出现泵衰竭迹象和有不良重构风险因素(如 MVO)的患者。本综述重点介绍了心脏 MRI 在 AMI 患者评估中的作用。