Bioinformatics Research, National Marrow Donor Program (NMDP), Minneapolis, MN, USA.
Int J Immunogenet. 2013 Feb;40(1):66-71. doi: 10.1111/iji.12031. Epub 2012 Dec 26.
This project has the goal to validate bioinformatics methods and tools for HLA haplotype frequency analysis specifically addressing unique issues of haematopoietic stem cell registry data sets. In addition to generating new methods and tools for the analysis of registry data sets, the intent is to produce a comprehensive analysis of HLA data from 20 million donors from the Bone Marrow Donors Worldwide (BMDW) database. This report summarizes the activity on this project as of the 16IHIW meeting in Liverpool.
本项目旨在验证生物信息学方法和工具,用于 HLA 单倍型频率分析,特别是针对造血干细胞登记数据集的独特问题。除了为登记数据集的分析生成新的方法和工具外,本项目还旨在对来自全球骨髓捐献者数据库(BMDW)的 2000 万供体的 HLA 数据进行全面分析。本报告总结了截至利物浦第 16 次 IHIW 会议的本项目的活动情况。