Maiers Martin, Gragert Loren, Klitz William
National Marrow Donor Program, Minneapolis, Minnesota, USA.
Hum Immunol. 2007 Sep;68(9):779-88. doi: 10.1016/j.humimm.2007.04.005. Epub 2007 May 24.
We extract and present high-resolution HLA allele and haplotype frequency data available from the National Marrow Donor Program databases from four major U.S. census categories of race and ethnicity. Population-based high-resolution HLA frequencies defined on the basis of from one to five loci are presented and made available online (http://bioinformatics.nmdp.org/haplotype2006). In addition, a discriminatory classification of HLA allelic variation on the basis of observed population allele frequencies (common, rare and unseen) for HLA A, C, B, DRB1, DQA1, and DQB1 is introduced. The electronic availability of this information will be useful for projects central to the typing and use of population data in HLA applications.
我们从美国国家骨髓捐献计划数据库中提取并呈现了来自美国四大种族和族裔普查类别的高分辨率HLA等位基因和单倍型频率数据。展示了基于一到五个位点定义的基于人群的高分辨率HLA频率，并在线提供（http://bioinformatics.nmdp.org/haplotype2006）。此外，还引入了基于观察到的HLA A、C、B、DRB1、DQA1和DQB1人群等位基因频率（常见、罕见和未见过的）对HLA等位基因变异进行的区分性分类。该信息的电子可用性将有助于HLA应用中人群数据分型和使用的核心项目。
