Kashani Ladan, Raisi Firoozeh, Saroukhani Sepideh, Sohrabi Hamid, Modabbernia Amirhossein, Nasehi Abbas-Ali, Jamshidi Amirhossein, Ashrafi Mandana, Mansouri Parisa, Ghaeli Padideh, Akhondzadeh Shahin
Infertility Ward, Arash Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Hum Psychopharmacol. 2013 Jan;28(1):54-60. doi: 10.1002/hup.2282. Epub 2012 Dec 20.
Saffron (Crocus sativus L.) has shown beneficial aphrodisiac effects in some animal and human studies. The aim of the present study was to assess the safety and efficacy of saffron on selective serotonin reuptake inhibitor-induced sexual dysfunction in women.
This was a randomized double-blind placebo-controlled study. Thirty-eight women with major depression who were stabilized on fluoxetine 40 mg/day for a minimum of 6 weeks and had experienced subjective feeling of sexual dysfunction entered the study. The patients were randomly assigned to saffron (30 mg/daily) or placebo for 4 weeks. Measurement was performed at baseline, week 2, and week 4 using the Female Sexual Function Index (FSFI). Side effects were systematically recorded.
Thirty-four women had at least one post-baseline measurement and completed the study. Two-factor repeated measure analysis of variance showed significant effect of time × treatment interaction [Greenhouse-Geisser's corrected: F(1.580, 50.567) = 5.366, p = 0.012] and treatment for FSFI total score [F(1, 32) = 4.243, p = 0.048]. At the end of the fourth week, patients in the saffron group had experienced significantly more improvement in total FSFI (p < 0.001), arousal (p = 0.028), lubrication (p = 0.035), and pain (p = 0.016) domains of FSFI but not in desire (p = 0.196), satisfaction (p = 0.206), and orgasm (p = 0.354) domains. Frequency of side effects was similar between the two groups.
It seems saffron may safely and effectively improve some of the fluoxetine-induced sexual problems including arousal, lubrication, and pain.
在一些动物和人体研究中,藏红花(番红花)已显示出有益的壮阳作用。本研究的目的是评估藏红花对女性选择性5-羟色胺再摄取抑制剂所致性功能障碍的安全性和有效性。
这是一项随机双盲安慰剂对照研究。38名患有重度抑郁症的女性进入本研究,她们服用40毫克/天氟西汀至少6周病情稳定且有性功能障碍的主观感受。患者被随机分配至藏红花组(30毫克/天)或安慰剂组,为期4周,并在基线、第2周和第4周使用女性性功能指数(FSFI)进行测量。系统记录副作用。
34名女性至少进行了一次基线后测量并完成了研究。双因素重复测量方差分析显示,时间×治疗交互作用有显著影响[Greenhouse-Geisser校正:F(1.580, 50.567) = 5.366, p = 0.012],且治疗对FSFI总分有显著影响[F(1, 32) = 4.243, p = 0.048]。在第4周结束时,藏红花组患者在FSFI的总评分(p < 0.001)、性唤起(p = 0.028)、润滑(p = 0.035)和疼痛(p = 所016)方面有显著改善,但在性欲(p = 0.196)、满意度(p = 0.206)和性高潮(p = 0.354)方面没有改善。两组间副作用发生频率相似。
藏红花似乎可以安全有效地改善一些由氟西汀引起的性问题,包括性唤起、润滑和疼痛。