Sahraian Ali, Jelodar Sina, Javid Zahra, Mowla Arash, Ahmadzadeh Laaya
Research Centre for Psychiatry and Behavioral Sciences, Department of Psychiatry, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Substance Abuse and Mental Health Research Center, Department of Psychiatry, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Asian J Psychiatr. 2016 Aug;22:174-6. doi: 10.1016/j.ajp.2015.10.012. Epub 2015 Nov 10.
Depression is a one of the most prevalent psychiatric disorder. Despite several pharmacological treatments, still treating depression is a challenge. Herbal medicine that is better culturally accepted may play an important role in treatment of depression. In this double blind placebo controlled clinical trial, 40 patients that were suffering from major depression according to DSM-IV criteria were randomly allocated to take either fluoxetine and saffron (20 patients) or fluoxetine and placebo (20 patients). The patients of the two groups were evaluated with Beck depression scale at the beginning of the study and after four weeks. Lipid profile (total Triglyceride (TG) level, total cholesterol level, low density lipoprotein (LDL) level and high density lipoprotein (HDL) level) of the patients also was measured at the beginning and end of the trial. 30 patients (19 in saffron group and 11 in placebo group) completed the study. The two groups improved significantly in depression severity at the end of the study without significant difference (P: 0.560). The lipid profile of the two groups did not change significantly. Our study did not demonstrate antidepressive effects for saffron. We did not observe any lipid lowering effect in saffron group too. Of note is that our study is preliminary and larger studies with more patients and longer duration are needed to prove our results.
IRCT 2013110915334.
抑郁症是最常见的精神疾病之一。尽管有多种药物治疗方法，但治疗抑郁症仍然是一项挑战。在文化上更容易被接受的草药可能在抑郁症治疗中发挥重要作用。在这项双盲安慰剂对照临床试验中，40名根据《精神疾病诊断与统计手册》第四版标准患有重度抑郁症的患者被随机分配，分别服用氟西汀和藏红花（20名患者）或氟西汀和安慰剂（20名患者）。两组患者在研究开始时和四周后用贝克抑郁量表进行评估。患者的血脂谱（总甘油三酯（TG）水平、总胆固醇水平、低密度脂蛋白（LDL）水平和高密度脂蛋白（HDL）水平）也在试验开始和结束时进行测量。30名患者（藏红花组19名，安慰剂组11名）完成了研究。研究结束时，两组的抑郁严重程度均有显著改善，但无显著差异（P：0.560）。两组的血脂谱没有显著变化。我们的研究未证明藏红花有抗抑郁作用。我们在藏红花组也未观察到任何降脂作用。值得注意的是，我们的研究是初步的，需要更多患者参与、持续时间更长的更大规模研究来证实我们的结果。
IRCT 2013110915334。
