Trojani M, Mongodin B, Seniuta P, Eghbali H, de Mascarel I, Coindre J M
Laboratoire d'anatomie pathologique, Fondation Bergonié, Bordeaux.
Ann Pathol. 1990;10(1):28-33.
Five cases of primary non-Hodgkin's lymphomas of the breast (stage IE in the Ann Arbor staging system) are described. No clinical or radiological feature has permitted to make the diagnosis before surgery. Histologically, all lymphomas are diffuse and B type. Three cases are high grade lymphomas, one of lymphoblastic type. Two cases are of lymphoplasmacytoid type, one of them associated with an occult invasive ductal carcinoma within the same breast, the other changing in high grade lymphoma at the recurrence time. Three of them reveal histological aspects of lymphoepithelial lesions and appear as mucosa-associated lymphoid tissue lymphomas (MALT). The differential diagnosis with a carcinoma is now easily done by immunohistochemical techniques. The importance of a diagnosis before surgery by cytopunction and drill-biopsy has to be emphasized, to prevent an useless mastectomy.
本文描述了5例原发性乳腺非霍奇金淋巴瘤（Ann Arbor分期系统中的IE期）。术前没有任何临床或影像学特征能够确诊。组织学上，所有淋巴瘤均为弥漫性B型。3例为高级别淋巴瘤，其中1例为淋巴母细胞型。2例为淋巴浆细胞样型，其中1例与同侧乳腺隐匿性浸润性导管癌相关，另一例在复发时转变为高级别淋巴瘤。其中3例显示淋巴上皮病变的组织学特征，表现为黏膜相关淋巴组织淋巴瘤（MALT）。现在通过免疫组化技术很容易与癌进行鉴别诊断。必须强调术前通过细针穿刺和钻取活检进行诊断的重要性，以避免不必要的乳房切除术。
