Institut Guttmann, Institut Universitari de Neurorehabilitació adscrit a la UAB, Badalona, Barcelona, Spain; Universitat Autònoma de Barcelona, Bellaterra (Cerdanyola del Vallès), Spain.
Neurourol Urodyn. 2013 Sep;32(7):1004-9. doi: 10.1002/nau.22359. Epub 2012 Dec 31.
To investigate the effects of subject controlled dorsal genital nerve (DGN) electrical stimulation on neurogenic detrusor overactivity (NDO) in subjects at home.
Subjects underwent a 5-day study at home with DGN stimulation. Stimulation was provided with surface electrodes placed either on the dorsal penile shaft in males and on or close to the clitoris in females. The days 1 and 5 were with no stimulation whereas days 2-4 were with stimulation. Two urodynamic studies were performed at the beginning and at the end of the study. A bladder diary was obtained.
Eleven subjects with NDO and with urge incontinence were included. One subject stopped the protocol before the end of the 5-day trial and two did not undergo the second urodynamic study. The subjects showed a statistically significant increase in bladder capacities compared to baseline (P = 0.047). Mean volume per day voided significantly increased over the study within the subjects. Differences between day 1 and day 5 were statistically significant (P = 0.028).
The feasibility and the globally positive outcomes of the study indicate that the stimulation of the dorsal genital nerve can be an option for the treatment of the NDO.
在家中研究受试者控制的阴部背神经（DGN）电刺激对神经源性逼尿肌过度活动（NDO）的影响。
受试者在家中进行了为期 5 天的研究，接受 DGN 刺激。刺激采用表面电极进行，男性放置在阴茎背部，女性放置在或靠近阴蒂。第 1 天和第 5 天不进行刺激，第 2 天至第 4 天进行刺激。在研究开始和结束时进行了两次尿动力学研究，并获得了膀胱日记。
共纳入 11 例 NDO 合并急迫性尿失禁患者。1 例受试者在 5 天试验结束前停止了方案，2 例受试者未进行第二次尿动力学研究。与基线相比，受试者的膀胱容量有统计学显著增加（P=0.047）。受试者在研究期间每天的平均排尿量显著增加。第 1 天和第 5 天之间的差异具有统计学意义（P=0.028）。
研究的可行性和总体积极结果表明，阴部背神经刺激可能是治疗 NDO 的一种选择。
