Gill S S, Bevan D R, Donati F
Department of Anaesthesia, Royal Victoria Hospital, Montreal, Quebec, Canada.
Br J Anaesth. 1990 Mar;64(3):300-5. doi: 10.1093/bja/64.3.300.
To determine the influence of enflurane on the ability of edrophonium to antagonize atracurium block, dose-response curves were constructed for edrophonium in the presence of 0%, 1% and 2% enflurane, and for 2% enflurane discontinued at the time of administration of edrophonium. One hundred ASA Physical Status I or II patients (four groups of 25), selected randomly and undergoing elective surgery, received atracurium 0.5 mg kg-1, with thiopentone, nitrous oxide and enflurane. Supplementary doses of fentanyl were given if needed. Train-of-four (TOF) stimulation was applied every 12 s, and the force of contraction of the adductor pollicis muscle was recorded. When first twitch height (T1) had recovered spontaneously to 10% of initial value, edrophonium 0.1, 0.2, 0.4 or 1 mg kg-1 was administered by random allocation. Enflurane concentrations remained constant, except that enflurane was discontinued in 50% of the patients who had received 2% enflurane. Monitoring was continued for at least 10 min, at which time T1 and TOF ratio (T4/T1) were measured. The ED80 for T1 recovery depended on the dose of enflurane: 0.08 (SEM 0.03), 0.21 (0.06) and 0.42 (0.18) mg kg-1 for 0%, 1% and 2% enflurane, respectively (P less than 0.005). With enflurane 2% discontinued, the ED80 was 0.095 (0.050) mg kg-1 (P less than 0.02 compared with 2% enflurane).(ABSTRACT TRUNCATED AT 250 WORDS)
为确定恩氟烷对依酚氯铵拮抗阿曲库铵阻滞能力的影响，分别构建了在0%、1%和2%恩氟烷存在时依酚氯铵的剂量-反应曲线，以及在给予依酚氯铵时停用2%恩氟烷的剂量-反应曲线。随机选取100例ASA身体状况I或II级、接受择期手术的患者（分四组，每组25例），给予阿曲库铵0.5mg/kg，同时使用硫喷妥钠、氧化亚氮和恩氟烷。必要时追加芬太尼。每12秒施加一次四个成串刺激（TOF），记录拇内收肌的收缩力。当单次颤搐高度（T1）自发恢复至初始值的10%时，随机给予依酚氯铵0.1、0.2、0.4或1mg/kg。恩氟烷浓度保持恒定，但接受2%恩氟烷的患者中有50%停用恩氟烷。持续监测至少10分钟，此时测量T1和TOF比值（T4/T1）。T1恢复的ED80取决于恩氟烷的剂量：0%、1%和2%恩氟烷时分别为0.08（标准误0.03）、0.21（0.06）和0.42（0.18）mg/kg（P<0.005）。停用2%恩氟烷时，ED80为0.095（0.050）mg/kg（与2%恩氟烷相比，P<0.02）。（摘要截短于250字）
