血清 α1-抗胰蛋白酶水平作为儿童炎症性肠病活动的标志物。

Serum α1-Antitrypsin Levels as a Marker of Activity in Pediatric Inflammatory Bowel Disease.

机构信息

Division of Pediatric Gastroenterology and Nutrition, Schneider Children's Hospital-Long Island Jewish Medical Center, Long Island Campus for the Albert Einstein College of Medicine, New Hyde Park, New York, U.S.A.

出版信息

Inflamm Bowel Dis. 1996 Fall;2(3):168-72.

PMID:23282561

Abstract

: The purpose of this study was to evaluate the use of the acute-phase serum protein α1-antitrypsin (α1-AT) compared with the erythrocyte sedimentation rate (ESR), platelet count, and hemoglobin level in screening for inflammation in newly diagnosed and known patients with inflammatory bowel disease (IBD). The serum α1-AT level, ESR, platelet count, and hemoglobin values of 154 children who were initially evaluated for possible IBD, as well as of 113 children with known IBD, were compared to evaluate their value as markers of inflammatory activity. Of the 154 children evaluated for IBD, 103 did not have IBD, 28 were diagnosed with Crohn's disease (CD), and 23 were found to have ulcerative colitis (UC). The sensitivity and specificity for CD was for α1-AT, 100%, 92%; for ESR, 68%, 94%; and for UC was for α1-AT, 70%, 92%; for ESR, 61%, 94%. In the 113 children with known IBD (66 CD, 47 UC), the sensitivity and specificity for predicting disease activity was for CD for α1-AT, 94%, 59%; for ESR, 52%, 63%; and for UC was for α1-AT, 79%, 76%; and for ESR, 59%, 82%. The determination of serum α1-AT levels was more sensitive and specific than the ESR in the initial diagnosis of CD and in predicting subsequent disease activity in both CD and UC.

摘要

本研究旨在评估急性相血清蛋白α1-抗胰蛋白酶（α1-AT）与红细胞沉降率（ESR）、血小板计数和血红蛋白水平在初诊和已知炎症性肠病（IBD）患者炎症筛查中的应用。比较了 154 例初诊疑似 IBD 患儿和 113 例已知 IBD 患儿的血清α1-AT 水平、ESR、血小板计数和血红蛋白值，以评估其作为炎症活动标志物的价值。在评估 IBD 的 154 例患儿中，103 例无 IBD，28 例诊断为克罗恩病（CD），23 例溃疡性结肠炎（UC）。CD 的α1-AT 的敏感性和特异性为 100%、92%，ESR 为 68%、94%；UC 的α1-AT 的敏感性和特异性为 70%、92%，ESR 为 61%、94%。在 113 例已知 IBD（66 例 CD，47 例 UC）患儿中，预测疾病活动的敏感性和特异性为 CD 的α1-AT 为 94%、59%，ESR 为 52%、63%；UC 的α1-AT 为 79%、76%，ESR 为 59%、82%。在 CD 的初诊和预测 CD 和 UC 后续疾病活动中，血清α1-AT 水平的测定比 ESR 更敏感和特异。