使用基于手性冠醚的手性固定相通过高效液相色谱法对伯胺化合物进行对映体拆分。
Enantioseparations of primary amino compounds by high-performance liquid chromatography using chiral crown ether-based chiral stationary phase.
作者信息
Hyun Myung Ho
机构信息
Department of Chemistry and Chemistry, Pusan National University, Busan, South Korea.
出版信息
Methods Mol Biol. 2013;970:165-76. doi: 10.1007/978-1-62703-263-6_9.
Liquid chromatographic resolution of racemic compounds containing a primary amino group has been known to be most successful when chiral crown ether-based chiral stationary phases (CSPs) are used. Among various crown ether-based CSPs, the stationary phase based on (+)-(18-crown-6)-2,3,11,12-tetracarboxylic acid covalently bonded to silica gel has been successfully applied in the resolution of various racemic compounds containing primary amino groups. In this chapter, the preparation of the CSP based on (+)-(18-crown-6)-2,3,11,12-tetracarboxylic acid covalently bonded to silica gel and examples for the application to the enantioseparation of racemic compounds including α-amino acids, cyclic amines, amino alcohols, and chiral drugs are described.
已知当使用基于手性冠醚的手性固定相（CSP）时，含有伯氨基的外消旋化合物的液相色谱拆分最为成功。在各种基于冠醚的CSP中，基于（+）-（18-冠-6）-2,3,11,12-四羧酸共价键合到硅胶上的固定相已成功应用于拆分各种含有伯氨基的外消旋化合物。在本章中，描述了基于（+）-（18-冠-6）-2,3,11,12-四羧酸共价键合到硅胶上的CSP的制备，以及将其应用于外消旋化合物对映体拆分的实例，这些外消旋化合物包括α-氨基酸、环胺、氨基醇和手性药物。
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