• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

（+）-（1S，5R，6R）-6- [（S）-1-羟基-2-（甲氧基甲氧基）乙基]-1-甲基-3-三氯甲基-2-氮杂-4,7-二氧杂双环-[3.3.0]辛-2-烯-8-酮

(+)-(1S,5R,6R)-6-[(S)-1-Hy-droxy-2-(meth-oxy-meth-yloxy)eth-yl]-1-methyl-3-trichloro-methyl-2-aza-4,7-dioxa-bicyclo-[3.3.0]oct-2-en-8-one.

作者信息

Oishi Takeshi, Oishi Hiroki, Tsuzaki Syun, Sato Takaaki, Chida Noritaka

机构信息

School of Medicine, Keio University, Hiyoshi 4-1-1, Kohoku-ku, Yokohama 223-8521, Japan.

出版信息

Acta Crystallogr Sect E Struct Rep Online. 2012 Nov 1;68(Pt 11):o3185. doi: 10.1107/S1600536812042912. Epub 2012 Oct 20.

DOI:10.1107/S1600536812042912
PMID:23284496
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3515276/
Abstract

In the title compound, C(11)H(14)Cl(3)NO(6), the fused five-membered oxazoline and tetra-hydro-furan rings are essentially planar with maximum deviations of 0.069 (1) and 0.031 (1) Å, respectively, and make a dihedral angle of 64.23 (11)° with each other. In the crystal, mol-ecules are linked by O-H⋯O and C-H⋯O hydrogen bonds, forming chains along the b-axis direction. Further C-H⋯O hydrogen bonds are observed between the chains.

摘要

在标题化合物C₁₁H₁₄Cl₃NO₆中，稠合的五元恶唑啉环和四氢呋喃环基本呈平面状，最大偏差分别为0.069 (1) Å和0.031 (1) Å，且彼此间形成的二面角为64.23 (11)°。在晶体中，分子通过O—H⋯O和C—H⋯O氢键相连，沿b轴方向形成链状结构。在这些链之间还观察到进一步的C—H⋯O氢键。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/623b/3515276/2faa8a3f0f38/e-68-o3185-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/623b/3515276/73b091c0947c/e-68-o3185-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/623b/3515276/2faa8a3f0f38/e-68-o3185-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/623b/3515276/73b091c0947c/e-68-o3185-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/623b/3515276/2faa8a3f0f38/e-68-o3185-fig2.jpg

相似文献

1
(+)-(1S,5R,6R)-6-[(S)-1-Hy-droxy-2-(meth-oxy-meth-yloxy)eth-yl]-1-methyl-3-trichloro-methyl-2-aza-4,7-dioxa-bicyclo-[3.3.0]oct-2-en-8-one.（+）-（1S，5R，6R）-6- [（S）-1-羟基-2-（甲氧基甲氧基）乙基]-1-甲基-3-三氯甲基-2-氮杂-4,7-二氧杂双环-[3.3.0]辛-2-烯-8-酮
Acta Crystallogr Sect E Struct Rep Online. 2012 Nov 1;68(Pt 11):o3185. doi: 10.1107/S1600536812042912. Epub 2012 Oct 20.
2
2-Eth-oxy-6-{[1-(3-eth-oxy-2-hy-droxy-benz-yl)-1H-benzimidazol-2-yl]meth-yl}phenol nitro-methane monosolvate.2-乙氧基-6-{[1-(3-乙氧基-2-羟基苄基)-1H-苯并咪唑-2-基]甲基}苯酚硝基甲烷单溶剂合物
Acta Crystallogr Sect E Struct Rep Online. 2012 Jun 1;68(Pt 6):o1914. doi: 10.1107/S1600536812023665. Epub 2012 May 31.
3
Crystal structures of (±)-(1SR,5SR,6SR,7SR,10SR,11SR,13RS,14SR)-13-hy-droxy-7-meth-oxy-meth-oxy-11,15,18,18-tetra-methyl-3-oxo-2,4-dioxa-tetra-cyclo-[12.3.1.0(1,5).0(6,11)]octa-dec-15-en-10-yl benzoate, its 13-epimer and 13-one derivative.（±）-（1SR，5SR，6SR，7SR，10SR，11SR，13RS，14SR）-13-羟基-7-甲氧基甲氧基-11，15，18，18-四甲基-3-氧代-2，4-二氧杂四环-[12.3.1.0（1，5）.0（6，11）]十八碳-15-烯-10-基苯甲酸酯及其13-差向异构体和13-酮衍生物的晶体结构
Acta Crystallogr E Crystallogr Commun. 2015 Apr 9;71(Pt 5):466-72. doi: 10.1107/S2056989015006854. eCollection 2015 May 1.
4
(Z)-1-(2-Hy-droxy-eth-yl)-4-(2-meth-oxy-benzyl-idene)-2-methyl-1H-imidazol-5(4H)-one.（Z）-1-（2-羟乙基）-4-（2-甲氧基亚苄基）-2-甲基-1H-咪唑-5（4H）-酮
Acta Crystallogr Sect E Struct Rep Online. 2013 Mar 28;69(Pt 4):o604-5. doi: 10.1107/S1600536813007770. Print 2013 Apr 1.
5
Crystal structure of (5R)-5-[(1S)-1,2-di-hydroxy-eth-yl]-4-meth-oxy-3-phenyl-2,5-di-hydro-furan-2-one.(5R)-5-[(1S)-1,2-二羟基乙基]-4-甲氧基-3-苯基-2,5-二氢呋喃-2-酮的晶体结构
Acta Crystallogr Sect E Struct Rep Online. 2014 Sep 30;70(Pt 10):o1141-2. doi: 10.1107/S1600536814021370. eCollection 2014 Oct 1.
6
Crystal structure of (+)-(1,5,6,7,10,11,16)-16-hy-droxy-7-(meth-oxy-meth-oxy)-11,15,18,18-tetra-methyl-3,13-dioxo-2,4-dioxa-tetra-cyclo[12.3.1.0.0]octa-dec-14-en-10-yl benzoate.(+)-(1,5,6,7,10,11,16)-16-羟基-7-(甲氧基甲氧基)-11,15,18,18-四甲基-3,13-二氧代-2,4-二氧杂四环[12.3.1.0.0]十八碳-14-烯-10-基苯甲酸酯的晶体结构
Acta Crystallogr E Crystallogr Commun. 2021 Nov 4;77(Pt 12):1234-1238. doi: 10.1107/S2056989021011518. eCollection 2021 Dec 1.
7
(E)-Methyl 2-({2-eth-oxy-6-[(E)-(hy-droxy-imino)-meth-yl]phen-oxy}meth-yl)-3-phenyl-acrylate.（E）-2-（{2-乙氧基-6-[(E)-(羟基亚氨基)甲基]苯氧基}甲基）-3-苯基丙烯酸甲酯
Acta Crystallogr Sect E Struct Rep Online. 2012 May 1;68(Pt 5):o1373. doi: 10.1107/S1600536812014596. Epub 2012 Apr 13.
8
(1S*,4'S*,5R*)-1-Isobutyl-5-meth-oxy-2',3-dimethyl-4,6-dioxa-2-aza-spiro-[bicyclo-[3.2.0]hept-2-ene-7,4'-isoquinoline]-1',3'(2'H,4'H)-dione.（1S*，4'S*，5R*）-1-异丁基-5-甲氧基-2'，3-二甲基-4,6-二氧杂-2-氮杂-螺[双环-[3.2.0]庚-2-烯-7,4'-异喹啉]-1'，3'（2'H，4'H）-二酮
Acta Crystallogr Sect E Struct Rep Online. 2011 May 1;67(Pt 5):o1273-4. doi: 10.1107/S1600536811015327. Epub 2011 Apr 29.
9
4-{[Bis(2-hy-droxy-eth-yl)amino]-meth-yl}-6-meth-oxy-2H-chromen-2-one.4-{[双（2-羟乙基）氨基]甲基}-6-甲氧基-2H-色原酮-2-酮
Acta Crystallogr Sect E Struct Rep Online. 2012 Aug 1;68(Pt 8):o2413-4. doi: 10.1107/S1600536812030759. Epub 2012 Jul 10.
10
(E)-N'-(3-Eth-oxy-4-hy-droxy-benzyl-idene)-4-meth-oxy-benzohydrazide.（E）-N'-（3-乙氧基-4-羟基苯亚甲基）-4-甲氧基苯甲酰肼
Acta Crystallogr Sect E Struct Rep Online. 2012 Mar 1;68(Pt 3):o849-50. doi: 10.1107/S1600536812007374. Epub 2012 Feb 24.

本文引用的文献

1
A short history of SHELX.SHELX简史。
Acta Crystallogr A. 2008 Jan;64(Pt 1):112-22. doi: 10.1107/S0108767307043930. Epub 2007 Dec 21.
2
Sphingofungins A, B, C, and D; a new family of antifungal agents. I. Fermentation, isolation, and biological activity.
J Antibiot (Tokyo). 1992 Jun;45(6):861-7. doi: 10.7164/antibiotics.45.861.
3
Sphingofungins E and F: novel serinepalmitoyl transferase inhibitors from Paecilomyces variotii.
J Antibiot (Tokyo). 1992 Oct;45(10):1692-6. doi: 10.7164/antibiotics.45.1692.