Konishi H, Sakurai M, Nakao H, Maseki N, Kaneko Y, Yagiri Y, Notohara K, Frizzera G
Department of Internal Medicine, Kurashiki Central Hospital, Okayama, Japan.
Cancer Res. 1990 May 1;50(9):2698-703.
Clonal chromosomal abnormalities were found in tumor tissue of 43 (84%) of 51 patients with non-Hodgkin's lymphoma (B-cell, 32; T-cell, 15) from an adult T-cell leukemia/lymphoma-nonendemic area in western mainland Japan. Four tumors were tetraploid, and the other 39 had a chromosome number in the diploid range. Trisomies 3, 5, 7, 18, and X, monosomy 13, and loss of an X in female and a Y in male were found in more than three patients each. Structural abnormalities in arms 1p, 1q, 2q, 3q, 13q, 14q, and 18q were found in eight or more patients each. Clustering of breaks occurred in 3q25-29 (ten patients, nine of whom with a B-cell tumor), 11q13 (five patients), dir dup(12)(q13-15----q21-24) (four patients), 14q32 (12 patients), and 18q21 (seven patients). The 14q32 translocations were all associated with B-cell tumors. t(8;14) was seen in a small noncleaved cell lymphoma, t(11;14)(q13;q32) in one follicular and three intermediately differentiated lymphocytic lymphomas, and t(14;18)(q32;q21) in two follicular lymphomas and one diffuse small cleaved cell tumor. The translocation partner of 14q could not be determined in the other four patients, three of whom had der(18)t(18;?)(q21;?). The seven 18q21 abnormalities, including a novel translocation t(2;18)(p11;q21.3), all occurred in B-cell tumors; even in the absence of t(14;18), they were closely associated with lymphomas of follicular center cell origin (six of seven).
在日本西部大陆非成人T细胞白血病/淋巴瘤流行地区的51例非霍奇金淋巴瘤（B细胞型32例，T细胞型15例）患者的肿瘤组织中，发现43例（84%）存在克隆性染色体异常。4例肿瘤为四倍体，其他39例染色体数目在二倍体范围内。三体3、5、7、18和X，单体13，以及女性X染色体和男性Y染色体缺失在各3例以上患者中被发现。1p、1q、2q、3q、13q、14q和18q臂的结构异常在各8例以上患者中被发现。断裂聚集发生在3q25 - 29（10例患者，其中9例为B细胞肿瘤）、11q13（5例患者）、dir dup(12)(q13 - 15----q21 - 24)（4例患者）、14q32（12例患者）和18q21（7例患者）。14q32易位均与B细胞肿瘤相关。t(8;14)见于1例小无裂细胞淋巴瘤，t(11;14)(q13;q32)见于1例滤泡性和3例中度分化淋巴细胞性淋巴瘤，t(14;18)(q32;q21)见于2例滤泡性淋巴瘤和1例弥漫性小裂细胞肿瘤。另外4例患者中14q的易位伙伴无法确定，其中3例有der(18)t(18;?)(q21;?)。包括新的易位t(2;18)(p11;q21.3)在内的7例18q21异常均发生在B细胞肿瘤中；即使没有t(14;18)，它们也与滤泡中心细胞起源的淋巴瘤密切相关（7例中的6例）。
