Olejnik O, Weisbecker C A
Queen's Medical Centre, Nottingham University, England.
Clin Ther. 1990 Jan-Feb;12(1):2-11.
Research on the anti-inflammatory effects of prednisolone sodium phosphate and prednisolone acetate is reviewed critically and methodological problems in the study of ocular drugs are identified. A pharmacokinetic model of the absorption of water-insoluble drugs, such as prednisolone acetate, and water-soluble drugs, such as prednisolone sodium phosphate, is presented. The steps in the model are the drug elimination rate in the precornea and anterior chamber, the rate of drug dissolution, the rate of drug penetration into the cornea, and the rate of drug transport into the aqueous humor. Both prednisolone sodium phosphate and prednisolone acetate have been shown to have moderate to high anti-inflammatory effects, but it is concluded that the drug solution (prednisolone sodium phosphate) has certain advantages over the drug suspension (prednisolone acetate).
对泼尼松龙磷酸钠和醋酸泼尼松龙的抗炎作用进行了批判性综述，并确定了眼部药物研究中的方法学问题。提出了一种水不溶性药物（如醋酸泼尼松龙）和水溶性药物（如泼尼松龙磷酸钠）吸收的药代动力学模型。该模型中的步骤包括药物在前房角和前房的消除速率、药物溶解速率、药物渗透入角膜的速率以及药物转运至房水的速率。已表明泼尼松龙磷酸钠和醋酸泼尼松龙均具有中度至高抗炎作用，但得出的结论是，药物溶液（泼尼松龙磷酸钠）比药物混悬液（醋酸泼尼松龙）具有某些优势。
