Musson D G, Bidgood A M, Olejnik O
IOLAB Corporation (Division of Johnson & Johnson), Claremont, California.
J Ocul Pharmacol. 1991 Summer;7(2):175-82. doi: 10.1089/jop.1991.7.175.
Comparative corneal penetration studies in the literature with prednisolone sodium phosphate solution and prednisolone acetate suspension administered to rabbit eyes give conflicting results concerning the greater bioavailability of prednisolone acetate. A recent in vitro penetration study shows similar fluxes for both salt forms in terms of prednisolone, quantified by a specific HPLC assay. An in vivo comparison has been conducted in NZW rabbit eyes and shows similar bioavailability for both drugs. Prednisolone sodium phosphate, prednisolone acetate and the primary metabolite prednisolone are quantified by a specific HPLC assay in aqueous humor.
文献中对兔眼给予磷酸泼尼松龙钠溶液和醋酸泼尼松龙混悬液进行的比较性角膜渗透研究，在醋酸泼尼松龙生物利用度更高这一问题上得出了相互矛盾的结果。最近一项体外渗透研究表明，通过特定的高效液相色谱法测定，两种盐形式的泼尼松龙通量相似。已在新西兰白兔眼中进行了体内比较，结果显示两种药物的生物利用度相似。通过特定的高效液相色谱法对房水中的磷酸泼尼松龙钠、醋酸泼尼松龙及其主要代谢产物泼尼松龙进行定量分析。
