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用于前列腺聚焦治疗的磁共振成像兼容设备的研发。

Development of an MRI-compatible device for prostate focal therapy.

作者信息

Cepek Jeremy, Chronik Blaine, Lindner Uri, Trachtenberg John, Fenster Aaron

机构信息

Robarts Research Institute, Western University, London, Canada.

出版信息

Med Image Comput Comput Assist Interv. 2012;15(Pt 1):455-62. doi: 10.1007/978-3-642-33415-3_56.

DOI:10.1007/978-3-642-33415-3_56
PMID:23285583
Abstract

We present a device that has been developed for delivering prostate focal thermal therapy under magnetic resonance imaging (MRI) guidance. Unlike most existing devices, ours is capable of delivering needles to targets in the prostate without removing the patient from the scanner. This feature greatly reduces procedure time and increases accuracy. The device consists of a mechanical linkage encoded with optical incremental encoders, and is manually actuated. A custom magnetic resonance (MR) compatible alignment interface allows the user to manually align the device to its target with high accuracy in-bore in very short time. The use of manual actuation over motors greatly reduces the complexity and bulk of the system, making it much more compact and portable. This is important when dealing with such tight space constraints. Needle targeting experiments in gel phantoms have demonstrated the device's ability to deliver needles with an accuracy of 2.1 +/- 1.3 mm.

摘要

我们展示了一种已开发出的用于在磁共振成像(MRI)引导下进行前列腺聚焦热疗的设备。与大多数现有设备不同,我们的设备能够在不将患者移出扫描仪的情况下将针递送至前列腺内的靶点。这一特性极大地减少了手术时间并提高了准确性。该设备由一个配备光学增量编码器的机械连杆机构组成,并且是手动驱动的。一个定制的与磁共振(MR)兼容的对准接口允许用户在非常短的时间内在扫描 bore 内高精度地手动将设备对准其目标。使用手动驱动而非电机驱动极大地降低了系统的复杂性和体积,使其更加紧凑且便于携带。在处理如此严格的空间限制时这一点很重要。在凝胶体模中进行的针靶向实验已证明该设备能够以2.1 +/- 1.3毫米的精度递送针。

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引用本文的文献

1
MRI-guided biopsies and minimally invasive therapy for prostate cancer.磁共振成像引导下的前列腺癌活检及微创治疗
Indian J Urol. 2015 Jul-Sep;31(3):209-16. doi: 10.4103/0970-1591.159615.
2
Focal therapy for prostate cancer: rationale and treatment opportunities.前列腺癌的焦点治疗:基本原理和治疗机会。
Clin Oncol (R Coll Radiol). 2013 Aug;25(8):461-73. doi: 10.1016/j.clon.2013.05.002. Epub 2013 Jun 4.