Zhou Luping, Salvado Olivier, Dore Vincent, Bourgeat Pierrick, Raniga Parnesh, Villemagne Victor L, Rowe Christopher C, Fripp Jurgen
Australian e-Health Research Centre, CSIRO, Australia.
Med Image Comput Comput Assist Interv. 2012;15(Pt 2):220-7. doi: 10.1007/978-3-642-33418-4_28.
For clinical evaluation, assessing amyloid deposition with PiB-PET is desirable without requiring MR acquisition and associated fusion/segmentation techniques. A useful clinical tool is to estimate PiB-PET against the brain surface, which is however challenging using PET alone because of the lack of structural information. We propose a method to generate such estimate, where multiple atlases are selected and combined with local weights in a Bayesian framework. Qualitative and quantitative comparison with and without MRI are presented. Using PET only, the average error on the brain surface was around 13% compared to MRI-dependant method.
