Vashi Neelam, Hunt Raegan, Fischer Max, Meehan Shane, Pomeranz Miriam Keltz
The Ronald O. Perelman Department of Dermatology, New York University School of Medicine, USA.
Dermatol Online J. 2012 Dec 15;18(12):20.
Multiple endocrine neoplasia type 1 (MEN1) is a familial tumor syndrome with autosomal dominant inheritance. Cutaneous tumors in MEN1, which include multiple angiofibromas, collagenomas, and lipomas can easily be overlooked because of their subtle appearance. As markers of this tumor syndrome, recognition of the mucocutaneous manifestations of MEN1 is important in order to facilitate early interdisciplinary care and diagnosis of associated internal disease in both patients and family members.
1型多发性内分泌肿瘤(MEN1)是一种具有常染色体显性遗传的家族性肿瘤综合征。MEN1中的皮肤肿瘤,包括多发性血管纤维瘤、胶原瘤和脂肪瘤,由于其外观不明显,很容易被忽视。作为这种肿瘤综合征的标志物,识别MEN1的黏膜皮肤表现对于促进患者及其家庭成员的早期跨学科护理和相关内科疾病的诊断非常重要。