Centenary Institute of Cancer Medicine and Cell Biology and the Discipline of Dermatology, University of Sydney, Sydney, NSW, Australia.
Clin Exp Immunol. 2013 Feb;171(2):147-54. doi: 10.1111/cei.12027.
The dendritic cell (DC) lineage is remarkably heterogeneous. It has been postulated that specialized DC subsets have evolved in order to select and support the multitude of possible T cell differentiation pathways. However, defining the function of individual DC subsets has proven remarkably difficult, and DC subset control of key T cell fates such as tolerance, T helper cell commitment and regulatory T cell induction is still not well understood. While the difficulty in assigning unique functions to particular DC subsets may be due to sharing of functions, it may also reflect a lack of appropriate physiological in-vivo models for studying DC function. In this paper we review the limitations associated with many of the current DC models and highlight some of the underlying difficulties involved in studying the function of murine DC subsets.
树突状细胞 (DC) 谱系具有显著的异质性。有人假设，专门的 DC 亚群已经进化，以便选择和支持多种可能的 T 细胞分化途径。然而，证明个体 DC 亚群的功能非常困难，并且 DC 亚群对关键 T 细胞命运的控制，如耐受、辅助性 T 细胞的决定和调节性 T 细胞的诱导，仍然不太清楚。虽然将特定 DC 亚群的独特功能分配给特定的 DC 亚群可能是由于功能的共享，但这也可能反映了缺乏适当的生理体内模型来研究 DC 功能。在本文中，我们回顾了许多当前 DC 模型所存在的局限性，并强调了研究小鼠 DC 亚群功能所涉及的一些潜在困难。
