在急性早幼粒细胞白血病（APL）中，低 BAALC 基因表达可确定一组具有良好总生存和改善无复发生存的患者。
In acute promyelocytic leukemia (APL) low BAALC gene expression identifies a patient group with favorable overall survival and improved relapse free survival.
机构信息
Department of Hematology and Oncology, University Hospital Mannheim, University of Heidelberg, Heidelberg, Germany.
出版信息
Leuk Res. 2013 Apr;37(4):378-82. doi: 10.1016/j.leukres.2012.11.018. Epub 2012 Dec 31.
We evaluated the prognostic value of BAALC expression in 86 patients with acute promyelocytic leukemia (APL). At 10 years, the overall survival (OS) was 66% in all patients and 75% in patients who achieved a complete remission (CR). Patients in the BAALC(low) group showed an OS of 87% as compared to 60% in the BAALC(high) group (p=0.019). This difference was more pronounced in treatment responders (92% vs. 70%; p=0.035). In multivariate analyses low BAALC expression retained its prognostic relevance. In conclusion, BAALC expression analysis might be useful in further risk stratification in APL patients.
我们评估了 BAALC 表达在 86 例急性早幼粒细胞白血病（APL）患者中的预后价值。10 年时，所有患者的总生存率（OS）为 66%，完全缓解（CR）患者为 75%。BAALC（低）组患者的 OS 为 87%，而 BAALC（高）组为 60%（p=0.019）。在治疗应答者中，这种差异更为明显（92% vs. 70%；p=0.035）。多变量分析显示低 BAALC 表达仍具有预后相关性。总之，BAALC 表达分析可能有助于对 APL 患者进行进一步的危险分层。
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