• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

大鼠心脏线粒体中可能存在辅酶Q的中间池。

Possible existence of an intermediate pool of ubiquinone in rat heart mitochondria.

作者信息

Yamamoto T, Sugawara H, Shimizu S, Momose K

机构信息

Department of Pharmacology, School of Pharmaceutical Sciences, Showa University, Tokyo, Japan.

出版信息

Int J Biochem. 1990;22(1):89-91. doi: 10.1016/0020-711x(90)90082-e.

DOI:10.1016/0020-711x(90)90082-e
PMID:2328822
Abstract
  1. The existence of an intermediate pool of ubiquinone in intact mitochondria of rat heart was investigated. 2. The incorporation of [3H-methyl]S-adenosylmethionine into ubiquinone-9 was not influenced by the co-synthesis of the intermediate, 3-nonaprenyl-4-hydroxybenzoate. 3. In the intermediate-depleted mitochondria, the synthetic rate of the intermediate, 3-nonaprenyl-4-hydroxybenzoate was similar to that of ubiquinone. 4. The possible existence of 3-nonaprenyl-4-hydroxybenzoate as a metabolic pool under physiological condition is discussed.
摘要
  1. 对大鼠心脏完整线粒体中辅酶Q中间池的存在情况进行了研究。2. [3H-甲基]S-腺苷甲硫氨酸掺入辅酶Q-9不受中间体3-壬基-4-羟基苯甲酸共同合成的影响。3. 在中间体耗尽的线粒体中,中间体3-壬基-4-羟基苯甲酸的合成速率与辅酶Q的合成速率相似。4. 讨论了在生理条件下3-壬基-4-羟基苯甲酸作为代谢池可能存在的情况。

相似文献

1
Possible existence of an intermediate pool of ubiquinone in rat heart mitochondria.大鼠心脏线粒体中可能存在辅酶Q的中间池。
Int J Biochem. 1990;22(1):89-91. doi: 10.1016/0020-711x(90)90082-e.
2
Possible involvement of 3-hydroxymethylglutaryl-CoA reductase in determining the side-chain length of ubiquinone in rat heart.3-羟基-3-甲基戊二酰辅酶A还原酶可能参与大鼠心脏中泛醌侧链长度的决定过程。
Arch Biochem Biophys. 1991 Jan;284(1):35-9. doi: 10.1016/0003-9861(91)90259-l.
3
Ubiquinone biosynthesis by mitochondria, sonicated mitochondria, and mitoplasts of rat liver.
J Biochem. 1992 Mar;111(3):371-5. doi: 10.1093/oxfordjournals.jbchem.a123764.
4
Inhibition of ubiquinone synthesis in isolated rat heart under an ischemic condition.缺血条件下对离体大鼠心脏中泛醌合成的抑制作用。
Int J Biochem. 1990;22(5):477-80. doi: 10.1016/0020-711x(90)90260-a.
5
Nonaprenyl-4-hydroxybenzoate transferase, an enzyme involved in ubiquinone biosynthesis, in the endoplasmic reticulum-Golgi system of rat liver.
J Biol Chem. 1990 Jan 15;265(2):1158-64.
6
Identification of regulatory sites in the biosynthesis of ubiquinone in the perfused rat heart.灌注大鼠心脏中泛醌生物合成调控位点的鉴定
Arch Biochem Biophys. 1989 Feb 15;269(1):86-92. doi: 10.1016/0003-9861(89)90089-1.
7
Evidence that the decarboxylation reaction occurs before the first methylation in ubiquinone biosynthesis in rat liver mitochondria.大鼠肝线粒体中泛醌生物合成过程中脱羧反应在首次甲基化反应之前发生的证据。
Eur J Biochem. 1991 Jun 15;198(3):599-605. doi: 10.1111/j.1432-1033.1991.tb16056.x.
8
Ubiquinone reduction pattern in pigeon heart mitochondria. Identification of three distinct ubiquinone pools.鸽心线粒体中泛醌的还原模式。三种不同泛醌池的鉴定。
Biochem J. 1985 Aug 1;229(3):621-9. doi: 10.1042/bj2290621.
9
Inhibition of mitochondrial beta-oxidation in the heart by increased redox state of the ubiquinone pool.
Biochem Soc Trans. 1996 Aug;24(3):457S. doi: 10.1042/bst024457s.
10
Effects of detergents on the properties of 4-hydroxybenzoate. Polyprenyl transferase and the specificity of the polyprenyl pyrophosphate synthetic system in mitochondria.
Biochemistry. 1977 Feb 22;16(4):605-9. doi: 10.1021/bi00623a008.

引用本文的文献

1
Isolation and functional expression of human COQ2, a gene encoding a polyprenyl transferase involved in the synthesis of CoQ.人类COQ2的分离与功能表达,COQ2是一种参与辅酶Q合成的聚异戊二烯转移酶编码基因。
Biochem J. 2004 Sep 1;382(Pt 2):519-26. doi: 10.1042/BJ20040261.
2
Effects of atovaquone and diospyrin-based drugs on ubiquinone biosynthesis in Pneumocystis carinii organisms.阿托伐醌和基于柿醌的药物对卡氏肺孢子虫中泛醌生物合成的影响。
Antimicrob Agents Chemother. 2000 Jan;44(1):14-8. doi: 10.1128/AAC.44.1.14-18.2000.