大鼠心脏线粒体中可能存在辅酶Q的中间池。
Possible existence of an intermediate pool of ubiquinone in rat heart mitochondria.
作者信息
Yamamoto T, Sugawara H, Shimizu S, Momose K
机构信息
Department of Pharmacology, School of Pharmaceutical Sciences, Showa University, Tokyo, Japan.
出版信息
Int J Biochem. 1990;22(1):89-91. doi: 10.1016/0020-711x(90)90082-e.
PMID:2328822
Abstract
- The existence of an intermediate pool of ubiquinone in intact mitochondria of rat heart was investigated. 2. The incorporation of [3H-methyl]S-adenosylmethionine into ubiquinone-9 was not influenced by the co-synthesis of the intermediate, 3-nonaprenyl-4-hydroxybenzoate. 3. In the intermediate-depleted mitochondria, the synthetic rate of the intermediate, 3-nonaprenyl-4-hydroxybenzoate was similar to that of ubiquinone. 4. The possible existence of 3-nonaprenyl-4-hydroxybenzoate as a metabolic pool under physiological condition is discussed.
摘要
- 对大鼠心脏完整线粒体中辅酶Q中间池的存在情况进行了研究。2. [3H-甲基]S-腺苷甲硫氨酸掺入辅酶Q-9不受中间体3-壬基-4-羟基苯甲酸共同合成的影响。3. 在中间体耗尽的线粒体中，中间体3-壬基-4-羟基苯甲酸的合成速率与辅酶Q的合成速率相似。4. 讨论了在生理条件下3-壬基-4-羟基苯甲酸作为代谢池可能存在的情况。
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